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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Five fractions separated from Nannochloropsis oculata using solvent-solvent partition chromatography of 80% methanolic extract of N. oculata (NOM) followed by the open silica column chromatography of its hexane fraction (NOMH) for the anti-inflammatory on RAW 264.7 cells and anti-cancer activities on HL-60, A-549, HEP-3B, HCT-116, and SW-480 cancer cells. All the five fractions showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 macrophages cells with IC<sub>50</sub> values less than 6.25 μg mL<sup>−1</sup>. Moreover, 90% n-hexane column elution of NOMH (NOMH90) down-regulated lipopolysaccharide-stimulated protein levels of inducible nitric oxide synthase and cyclooxygenase-2. Furthermore, NOMH90 showed marked cytotoxic effect on the HL-60 cells with IC<sub>50</sub> value of 23.58 ± 0.09 μg mL<sup>−1</sup>. In addition, Hoechst 33342 cell permeable dye used to visualize the apoptosis nucleus and cell cycle analysis measured Sub-G1 DNA contents to confirm reduction of the cell viability in NOMH90 treated cells due to induction of apoptosis in HL60. These results are quite related to the phytosterol contents of the NOMH fractions and the results suggest N. oculata extracts might be useful as potential sources of natural anti-inflammatory and anti-cancer compounds. In conclusion, the sterol content in N. oculata might provide a promising role in future medicines in anti-inflammatory and anti-cancer.
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참고문헌 (47)
참고문헌 신청
Burke, R. W. / 1974 / Mechanisms of the Liebermann-Burchard and Zak color reactions for cholesterol / Clin. Chem 20:794~801
Calder, P. C. / 2006 / n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am. J. Clin. Nutr. 83(6 Suppl):1505S~1519S
Converti, A. / 2009 / Effect of temperature and nitrogen concentration on the growth and lipid content of Nannochloropsis oculata and Chlorella vulgaris for biodiesel production / Chem. Eng. Process. 48:1146~1151
Costa, P. M. / 2013 / Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells : a promising system for glioblastoma treatment / Mol. Ther. Nucleic Acids 2:e100
Cotter, T. G / 2009 / Apoptosis and cancer: the genesis of a research field / Nat. Rev. Cancer 9:501~507
Calder, P. C. / 2006 / n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am. J. Clin. Nutr. 83(6 Suppl):1505S~1519S
Converti, A. / 2009 / Effect of temperature and nitrogen concentration on the growth and lipid content of Nannochloropsis oculata and Chlorella vulgaris for biodiesel production / Chem. Eng. Process. 48:1146~1151
Costa, P. M. / 2013 / Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells : a promising system for glioblastoma treatment / Mol. Ther. Nucleic Acids 2:e100
Cotter, T. G / 2009 / Apoptosis and cancer: the genesis of a research field / Nat. Rev. Cancer 9:501~507
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