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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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This study evaluated the effects of γ-aminobutyric acid (GABA)-enriched fermented sea tangle (GFST), as a functional food, on brain derived neurotrophic factor (BDNF)-related muscle growth and lipolysis, in a sarcopenic obesity high-risk group. Twenty-one middle-aged women (53-63 y) participated in this randomized, double-blind, placebo controlled study. Participants ingested either 1,000 mg of GFST (n = 10) or a sucrose placebo (CON) (n = 11) everyday, for 8 weeks. Subjects were asked to abstain from any regular exercise. Fasting venous blood samples, body composition and muscular strength were measured before and after supplementation period. Collectively, we demonstrated that GFST significantly decreased total fat mass and triglyceride in body composition, as well as significantly increasing serum BDNF (p < 0.001), angiotensin converting enzyme (p < 0.001), human growth hormone and insulin-like growth factor-1 levels (p < 0.05 and p < 0.05, respectively) accompanied by increased total lean mass (p < 0.01). Furthermore, the reported improvements in total work, knee extension and flexion at 60° s<sup>−1</sup> (p < 0.05), and peak torque normalized to body weight of knee flexion at 60° s<sup>−1</sup> (p < 0.05), support an ergogenic effect of GABA associated with increased growth factor levels. The use of GFST, as a functional food ingredient, to elicit anti-obesity effects and stimulate the release of muscle-related growth factors with increasing serum BDNF levels may provide a protective intervention for age-related degeneration such as sarcopenic obesity.
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참고문헌 (58)
참고문헌 신청
Brink, M. / 2001 / Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I / Endocrinology 142:1489~1496
Cattaneo, A. / 2010 / Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment / Int. J. Neuropsychopharmacol 13:103~108
Cavagnini, F. / 1980 / Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone / J. Clin. Endocrinol. Metab 51:789~792
Cavagnini, F. / 1980 / Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man / Acta Endocrinol. (Copenh.) 93:149~154
차재영 / 2011 / Effect of Fermented Sea Tangle on the Alcohol Dehydrogenase and Acetaldehyde Dehydrogenase in Saccharomyces cerevisiae / Journal of Microbiology and Biotechnology 21(8):791~795
Cattaneo, A. / 2010 / Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment / Int. J. Neuropsychopharmacol 13:103~108
Cavagnini, F. / 1980 / Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone / J. Clin. Endocrinol. Metab 51:789~792
Cavagnini, F. / 1980 / Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man / Acta Endocrinol. (Copenh.) 93:149~154
차재영 / 2011 / Effect of Fermented Sea Tangle on the Alcohol Dehydrogenase and Acetaldehyde Dehydrogenase in Saccharomyces cerevisiae / Journal of Microbiology and Biotechnology 21(8):791~795
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