Results of Intravesical Chemo-Hyperthermia in High-risk Non-muscle Invasive Bladder Cancer

Ekin, Rahmi Gokhan; Akarken, Ilker; Cakmak, Ozgur; Tarhan, Huseyin; Celik, Orcun; Ilbey, Yusuf Ozlem; Divrik, Rauf Taner; Zorlu, Ferruh

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자료유형: 학술저널

저자정보: Ekin, Rahmi Gokhan (Department of Urology, Tepecik Teaching and Research Hospital) Akarken, Ilker (Urology Clinic, Kemalpasa State Hospital) Cakmak, Ozgur (Department of Urology, Tepecik Teaching and Research Hospital) Tarhan, Huseyin (Department of Urology, Tepecik Teaching and Research Hospital) Celik, Orcun (Department of Urology, Tepecik Teaching and Research Hospital) Ilbey, Yusuf Ozlem (Department of Urology, Tepecik Teaching and Research Hospital) Divrik, Rauf Taner (Department of Urology, Sifa University, Faculty of Medicine) Zorlu, Ferruh (Department of Urology, Tepecik Teaching and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제8호

발행연도: 2015.1

수록면: 3,241 - 3,245 (5page)

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Purpose: To examine the effectiveness of mitomycin-C and chemo-hyperthermia in combination for patients with high-risk non-muscle-invasive bladder cancer. Materials and Methods: Between November 2011-September 2013, 43 patients with high-risk non-muscle-invasive bladder cancer undergoing adjuvant chemo-hyperthermia in two centers were evaluated retrospectively. Treatment consisted of 6 weekly sessions, followed by 6 sessions. Recurrence and progression rate, recurrence-free interval and side effects were examined. Analyzed factors included age, gender, smoking status, AB0 blood group, body mass index, T stage and grade, concominant CIS assets. The associations between predictors and recurrence were assessed using multivariate Cox proportional hazard analyses. Results: A total of 40 patients completed induction therapy. Thirteen (32.5%) were diagnosed with tumor recurrence. Median follow-up was 30 months (range 9-39). Median recurrence-free survival was 23 months (range 6-36). The Kaplan-Meier-estimated recurrence-free rates for the entire group at 12 and 24 months were 82% and 61%. There was no statistically significant difference between patient subgroups. Cox hazard analyses showed that an A blood type (OR=6.23, p=0.031) was an independent predictor of recurrence-free. Adverse effects were seen in 53% of patients and these were frequently grades 1 and 2. Conclusions: Intravesical therapy with combination of mitomycin-C and chemohyperthermia seems to be appropriate in high-risk patients with non-muscle-invasive bladder cancer who cannot tolerate or have contraindications for standard BCG therapy.

#Chemohyperthermia #recurrence #mitomycin C #thermochemotherapy #non muscle-invasive bladder cancer

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