Anti-cancer Properties of a Sesquiterpene Lactone-bearing Fraction from Artemisia khorassanica

Rabe, Shahrzad Taghizadeh; Emami, Seyed Ahmad; Iranshahi, Mehrdad; Rastin, Maryam; Tabasi, Nafise; Mahmoudi, Mahmoud

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자료유형: 학술저널

저자정보: Rabe, Shahrzad Taghizadeh (Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical Science) Emami, Seyed Ahmad (Department of Pharmacognosy, Mashhad University of Medical Science) Iranshahi, Mehrdad (Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Science) Rastin, Maryam (Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical Science) Tabasi, Nafise (Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical Science) Mahmoudi, Mahmoud (Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical Science)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 863 - 868 (6page)

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Background: Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for the effects. Materials and Methods: Anti-cancer potential was evaluated by toxicity against human melanoma and fibroblast cell lines. To explore the involved pathways, pattern of any cell death was determined using annexin-V/PI staining and also the expression of Bax and cytochrome c was investigated by Western blotting. Results: The results showed that SLAK selectively caused a concentration-related inhibition of proliferation of melanoma cells that was associated with remarkable increase in early events and over-expression of both Bax and cytochrome c. Conclusions: The current experiment indicates that Artemisia may have anti-cancer activity. We anticipate that the ingredients may be employed as therapeutic candidates for melanoma.

#Artemisia khorassanica #melanoma cell line #apoptosis #bax #cytochrome c

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Rabe, Shahrzad Taghizadeh

소속기관 Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Med