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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 107 - 115 (9page)
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초록· 키워드
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Human malignant melanoma is an aggressive skin cancer which has been rising at a greater rate than any other cancers.
Although various new therapeutic methods have been developed in previous studies, this disease has properties of high proliferation and metastasis rate which remain obstacles that have lead to a poor prognosis in patients. It has been reported that a specific Lactobacillus extract has anti-cancer and –metastasis effect in vitro and in vivo. However, previous research has not specified precisely what effect the Lactobacillus rhamnosus GG (LGG) extract has had on human malignant melanomas. In this study, we showed that the LGG extract has anti-cancer and –metastasis effects on the human malignant melanoma cell lines, A375P and A375SM. At first, it was found that, while the LGG extract affects human neonatal dermal fibroblasts slightly, it induced the dose-dependent anti-cancer effect on A375P and A375SM by a WST-1 proliferation assay. As a result of a real-time PCR analysis, the expression patterns of several genes related to cell cycle, proliferation, and apoptosis were modulating in a manner that inhibited the growth of both malignant melanoma cell lines after the treatment of the LGG extract. Furthermore, genes related to the epithelialmesenchymal transition were down-regulated, and migration rates were also decreased significantly by the LGG extract.
Our study showed that the LGG extract could be used as a potential therapeutic source.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Byung Lee / 2012 / Current management and novel agents for malignant melanoma / Journal of Hematology & Oncology 5 (1) : 3 ~
Charles M. Balch / 2009 / Final Version of 2009 AJCC Melanoma Staging and Classification / Journal of Clinical Oncology 27 (36) : 6199 ~ 6206
Chiu NT / 1996 / Melanoma of oronasal mucosa. Population-based analysis of occurrence and mortality / Arch Otolaryngol Head Neck Surg 122 : 985 ~ 988
D. S. Rigel / 2010 / The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs / CA: A Cancer Journal for Clinicians 60 (5) : 301 ~ 316
Dimitrakopoulos I / 1998 / Report of an unusual case / Aust Dent J 43 : 379 ~ 381
Charles M. Balch / 2009 / Final Version of 2009 AJCC Melanoma Staging and Classification / Journal of Clinical Oncology 27 (36) : 6199 ~ 6206
Chiu NT / 1996 / Melanoma of oronasal mucosa. Population-based analysis of occurrence and mortality / Arch Otolaryngol Head Neck Surg 122 : 985 ~ 988
D. S. Rigel / 2010 / The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs / CA: A Cancer Journal for Clinicians 60 (5) : 301 ~ 316
Dimitrakopoulos I / 1998 / Report of an unusual case / Aust Dent J 43 : 379 ~ 381
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