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Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status
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논문 기본 정보

Type
Academic journal
Author
Journal
영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제34권 제2호 KCI Accredited Journals
Published
2017.1
Pages
270 - 274 (5page)

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Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status
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A nodular density was detected on a chest radiograph taken from a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung; biopsies of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping to investigate the potential double primary lung cancer. The results verified that the mass in the right lung had a mutation in the epidermal growth factor receptor, whereas the nodule in the left lung had a wild-type sequence, showing that these two were genetically different cancers from one another. Thus, we demonstrate that genetic testing is useful in determining double primary lung cancer, and we herein report on this case
#Adenocarcinoma #Differential diagnosis #Lung cancer #DNA sequence analysis #Mutations

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Beyreuther H / 1924 / Multiplicitat von Carcinomen bei einem Fall von sog. 'Schneeberger' Lungenkrebs mit Tuberkulose / Virchows Arch Path Anat 250 : 230 ~ 243 google schola Chang YL / 2007 / Surgical treatment of synchronous multiple primary lung cancers: experience of 92 patients / J Thorac Cardiovasc Surg 134 : 630 ~ 637 google schola Chuang JC / 2016 / Concordant and discordant EGFR mutations in patients with multifocal adenocarcinomas: implications for EGFR-targeted therapy / Clin Ther 38 : 1567 ~ 1576 google schola Girard N / 2009 / Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers / Clin Cancer Res 15 : 5184 ~ 5190 google schola Girard N / 2010 / Use of epidermal growth factor receptor/Kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung ad google schola

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