Inflammatory Breast Cancer in Tunisia from 2005 to 2010: Epidemiologic and Anatomoclinical Transitions from Published Data

Mejri, N.; Boussen, H.; Labidi, S.; Bouzaiene, H.; Afrit, M.; Benna, F.; Rahal, K.

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저자정보: Mejri, N. (Department of Medical Oncology, University Hospital A Mami) Boussen, H. (Department of Medical Oncology, University Hospital A Mami) Labidi, S. (Department of Medical Oncology, University Hospital A Mami) Bouzaiene, H. (Department of Radiotherapy, Institute Salah Azaiez) Afrit, M. (Department of Medical Oncology, University Hospital A Mami) Benna, F. (Department of Radiotherapy, Institute Salah Azaiez) Rahal, K. (Department of Surgical Oncology, Institute Salah Azaiez)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 1,277 - 1,280 (4page)

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Aim: To report epidemiologic and anatomoclinical transitions of inflammatory breast cancer (IBC) in Tunisia. Materials and Methods: Data including clinico-pathological data for 208 cases of T4d or PEV 3 non-metastatic breast cancer diagnosed between 2005 and 2010 were collected from patient records. Chi2 and Z tests were used to compare variables with two Tunisian historical series and a series about Arab-American patients. Results: Thirty three percent of our patients had their first child before 23 years of age and 56% had their menarche before 12 years, 75% never receiving oral contraception. Obesity was observed in 42% of women and IBC occurred during pregnancy in 13% of cases. Tumor grade was II-III in 90% of cases, HR was negative in 52%, HER2 was over expressed in 31% and invasion of more than 3 axillary nodes occurred in 18% of patients. We observed a pCR rate of 19% after neoadjuvant treatment (anthracyline-taxane used in 79%, trastuzumab in 27% ). Compared to historical Tunisian series (since 1996), IBC epidemiology remained stable in terms of median age, menopausal status and obesity. However we observed a significant decrease in median clinical tumor size and number of positive axillary lymph nodes. Comparison to IBC in Arab-Americans showed a significant difference in terms of median age, menopausal status, positivity of hormonal receptors and educational level. Conclusions: Our assessment of epidemiologic transition showed a reduction of clinco-pathological stage of IBC, keeping the same characteristics as compared to Tunisian historical series over a period of 14 years. Features seem to be different in Arab-American patients, probably related to migration, "occidentalization" of life style and improvement in socio-economic level.

#Inflammatory breast cancer #epidemiology #ethnicity #Tunisia #Arab-Americans

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