Circulating Cell-free miRNA Expression and its Association with Clinicopathologic Features in Inflammatory and Non-Inflammatory Breast Cancer

Hamdi, K; Blancato, J; Goerlitz, D; Islam, MD; Neili, B; Abidi, A; Gat, A; Ayed, F Ben; Chivi, S; Loffredo, CA; Jillson, I; Elgaaied, A Benammar; Marrakchi, R

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저자정보: Hamdi, K (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El Manar) Blancato, J (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center) Goerlitz, D (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center) Islam, MD (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center) Neili, B (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El Manar) Abidi, A (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El Manar) Gat, A (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El Manar) Ayed, F Ben (Department of Medical Oncology, Hannibal International Clinic) Chivi, S (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center) Loffredo, CA (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center) Jillson, I (Lombardi Comprehensive Cancer Center, Georgetown University Medical Center) Elgaaied, A Benammar (Laboratory of Genetics, Immunology and Hum) Marrakchi, R

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제4호

발행연도: 2016.1

수록면: 1,801 - 1,810 (10page)

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Recent discovery showing the presence of microRNAs (miRNAs) in the circulation sparked interest in their use as potential biomarkers. Our previous studies showed the diagnostic potential of miR-451 as a serological marker for inflammatory breast cancer (IBC), miR-337-5p and miR-30b for non-inflammatory breast cancer (non-IBC). The aim of this study is to investigate the prognostic values of circulating miRNAs by comparing the amounts of 12 circulating miRNAs in the serum of IBC and non-IBC from Tunisian breast cancer patients, and by determinating whether correlated pairs of miRNAs could provide useful information in the diagnosis of IBC and non-IBC patients. TaqMan qPCR was performed to detect circulating expression of miRNAs in serum of 20 IBC, 20 non-IBC and 20 healthy controls. Nonparametric rank Spearman rho correlation coefficient was used to examine the prognostic value of miRNAs and to assess the correlation profile between miRNAs expression. Further, a large number of miRNAs were highly correlated (rho>0.5) in both patients groups and controls. Also, the correlations profiles were different between IBC, non-IBC and healthy controls indicating important changes in molecular pathways in cancer cells. Our results showed that miR-335 was significantly overexpressed in premenopausal non-IBC patients; miR-24 was significantly overexpressed in non-IBC postmenopausal patients. Patients with previous parity had higher serum of miR-342-5p levels than those without. Furthermore, patients with HER2+ IBC present lower serum levels of miR-15a than patients with HER2-disease. Together, these results underline the potential of miRNAs to function as diagnostic and prognostic markers for IBC and non-IBC, with links to the menopausal state, Her2 status and parity.

#Breast cancer #inflammatory breast cancer #circulating miRNAs #biomarker #prognostic #diagnostic

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Hamdi, K

소속기관 Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, University of Tunis El