Increased Expression of HOXB2 and HOXB13 Proteins is Associated with HPV Infection and Cervical Cancer Progression

Gonzalez-Herrera, A.L.; Salgado-Bernabe, M.; Velazquez-Velazquez, C.K.; Salcedo-Vargas, M.; Andrade-Manzano, A.; Avila-Moreno, F.; Pina-Sanchez, P.

추천

검색

자료유형: 학술저널

저자정보: Gonzalez-Herrera, A.L. (Laboratorio de Oncologia Molecular, Unidad de Investigacion Medica en Enfermedades Oncologicas CMN S XXI IMSS) Salgado-Bernabe, M. (Laboratorio de Oncologia Molecular, Unidad de Investigacion Medica en Enfermedades Oncologicas CMN S XXI IMSS) Velazquez-Velazquez, C.K. (Laboratorio de Oncologia Molecular, Unidad de Investigacion Medica en Enfermedades Oncologicas CMN S XXI IMSS) Salcedo-Vargas, M. (Laboratorio de Oncologia Genomica, Unidad de Investigacion Medica en Enfermedades Oncologicas CMN S XXI IMSS) Andrade-Manzano, A. (Departamento de Patologia Hospital de Ginecoobstetricia no. IMSS) Avila-Moreno, F. (Laboratorio de Epigenomica del Cancer, Unidad de Biomedicina FES-Iztacala, UNAM) Pina-Sanchez, P. (Laboratorio de Oncologia Molecular, Unidad de Investigacion Medica en Enfermedades Oncologicas CMN S XXI IMSS)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제4호

발행연도: 2015.1

수록면: 1,349 - 1,353 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Cervical cancer (CeCa) is the second most common cancer in women in developing countries, and human papilloma virus (HPV) is the primary etiological factor. Aberrant expression of HOX transcription factors has been observed in several types of cancer. To date, however, no reports exist on the expression of HOXB2 and HOXB13 proteins during neoplastic progression in CeCa and its correlation with HPV infection. Materials and Methods: Expression of HOXB2 and HOXB13 proteins was assessed in tissue microarrays from normal cervical epithelium, cervical intraepithelial neoplasias grade 1-3, and CeCa. HPV was detected by PCR and sequencing. Expression of HOX-positive cells was determined in each diagnostic group. Results: Percentage of HOXB2- and HOXB13-positive cells gradually increased from means of 10.9% and 16.7%, respectively, in samples from healthy women, to 75.2% and 88.6% in those from CeCa patients. Frequency of HPV infection also increased from 13% in healthy tissue samples to 92.3% in CeCa. Both HOXB2 and HOXB13 proteins were preferentially expressed in HPV+ samples. Conclusions: The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.

#Cervical cancer #HOXB2 and HOXB13 proteins #HPV infection #progression

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Gonzalez-Herrera, A.L.

소속기관 Laboratorio de Oncologia Molecular, Unidad de Investigacion Medica en Enfermedades Oncologicas CMN S