지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Investigation of human papillomavirus (HPV) in archival formalin-fixed paraffin-embedded (FFPE) material is important for understanding cervical carcinogenesis. The objective of the present study was to identify the high risk HPVs (HR-HPVs) using HPV E6/E7 mRNA testing from archival tissues in cervical cancer and the relation to HR-HPVs genotypes in paired cervical exfoliated cells. HPV E6/E7 mRNA testing and DNA chip testing were performed in 79 paired cervical FFPE tissues and exfoliated cells from women with histologically confirmed squamous cell carcinoma and adenocarcinoma. Overall agreement in HR-HPVs detection from FFPE samples and cytology samples were 98.5% in HPV 16, 100% in HPV 18, HPV 31, HPV 33, HPV 58, HPV 66, and HPV 68. Type-specific agreement between FFPE samples and cytology samples was 89.1% in HPV positive, 93.5% in HPV 16 and more than 70% in the other HR-HPVs. In conclusion, HR-HPVs were reliably detected in paired FFPE and cytology samples with some variation in type-specific detection.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] - Carozzi F / 2000 / Prediction of high-grade cervical intraepithelial neoplasia in cytologically normal women by human papillomavirus testing / British Journal of Cancer 83 : 1462 ~ 1467
[학술지(정기간행물)] - Carozzi M / 2010 / Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in italy / Cancer Epidemiology Biomarkers & Prevention 19 : 2389 ~ 2400
[학술지(정기간행물)] - Castle E / 2006 / Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: comparison of HPV risk group to cytology and histology / J Clin Microbiol 44 : 3915 ~ 3917
[학술지(정기간행물)] - Castro A / 2015 / Detection of HPV DNA in paraffin-embedded cervical samples: a comparison of four genotyping methods / BMC Infect Dis 15 : 544 ~
[학술지(정기간행물)] - De sanjose S / 2010 / Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study / Lancet Oncol 11 : 1048 ~ 1056
[학술지(정기간행물)] - Carozzi M / 2010 / Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in italy / Cancer Epidemiology Biomarkers & Prevention 19 : 2389 ~ 2400
[학술지(정기간행물)] - Castle E / 2006 / Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: comparison of HPV risk group to cytology and histology / J Clin Microbiol 44 : 3915 ~ 3917
[학술지(정기간행물)] - Castro A / 2015 / Detection of HPV DNA in paraffin-embedded cervical samples: a comparison of four genotyping methods / BMC Infect Dis 15 : 544 ~
[학술지(정기간행물)] - De sanjose S / 2010 / Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study / Lancet Oncol 11 : 1048 ~ 1056
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Combined SYBR Green real-time polymerase chain reaction and microarray method for the simultaneous determination of human papillomavirus loads and genotypes
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Investigation of human papillomavirus prevalence in married women and molecular characterization and phylogenetic analysis of the virus
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UCI(KEPA) : I410-ECN-0101-2017-510-001392581