지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 43 - 55 (13page)
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초록· 키워드
오류제보하기
Virus-like particles (VLPs) derived from human papillomavirus (HPV) L1 capsid proteins were used for HPV quadrivalent recombinant vaccine. The HPV quadrivalent vaccine is administrated in a 3-dose regimen of initial injection followed by subsequent doses at 2 and 6 months to prevent cervical cancer, vulvar, and vaginal cancers. The type 6, 11, 16, or 18 of HPV infection is associated with precancerous lesions and genital warts in adolescents and young women. The HPV vaccine is composed of viral L1 capsid proteins are produced in eukaryotic expression systems and purified in the form of VLPs. Four different the L1 protein of 3 different subtypes of HPV: HPV11, HPV16, and HPV18 were expressed in Escherichia coli divided into 2 fragments as N- and C-terminal of each protein in order to examine the efficacy of HPV vaccine. Vaccinated sera failed to recognize N-terminal L1 HPV type 16 and type 18 by western blot while they detected N-terminal L1 protein of HPV type 11. Moreover, the recombinant C-terminal L1 proteins of type 16 was non-specifically recognized by the secondary antibody conjugated with horseradish peroxidase. This expression and purification system may provide simple method to obtain robust recombinant L1 protein of HPV subtypes to improve biochemical analysis of antigens with immunized sera.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
Favre M / 1975 / Structural polypeptides of rabbit, bovine, and human papillomaviruses / J Virol 15:1239~1247
zur Hausen H / 1991 / Viruses in human cancers / Science 254:1167~1173
Clifford GM / 2005 / Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer / Cancer Epidemiol Biomarkers Prev 14:1157~1164
Burd EM / 2003 / Human papillomavirus and cervical cancer / Clin Microbiol Rev 16:1~17
Munoz N / 2003 / Epidemiologic classification of human papillomavirus types associated with cervical cancer / N Engl J Med 348:518~527
zur Hausen H / 1991 / Viruses in human cancers / Science 254:1167~1173
Clifford GM / 2005 / Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer / Cancer Epidemiol Biomarkers Prev 14:1157~1164
Burd EM / 2003 / Human papillomavirus and cervical cancer / Clin Microbiol Rev 16:1~17
Munoz N / 2003 / Epidemiologic classification of human papillomavirus types associated with cervical cancer / N Engl J Med 348:518~527
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UCI(KEPA) : I410-ECN-0101-2018-517-003105505