FoxM1 as a Novel Therapeutic Target for Cancer Drug Therapy

Xu, Xin-Sen; Miao, Run-Chen; Wan, Yong; Zhang, Ling-Qiang; Qu, Kai; Liu, Chang

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자료유형: 학술저널

저자정보: Xu, Xin-Sen (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) Miao, Run-Chen (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) Wan, Yong (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) Zhang, Ling-Qiang (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) Qu, Kai (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) Liu, Chang (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제1호

발행연도: 2015.1

수록면: 23 - 29 (7page)

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Background: Current cancer therapy mainly focuses on identifying novel targets crucial for tumorigenesis. The FoxM1 is of preference as an anticancer target, due to its significance in execution of mitosis, cell cycle progression, as well as other signal pathways leading to tumorigenesis. FoxM1 is partially regulated by oncoproteins or tumor suppressors, which are often mutated, lost, or overexpressed in human cancer. Since sustaining proliferating signaling is an important hallmark of cancer, FoxM1 is overexpressed in a series of human malignancies. Alarge-scale gene expression analysis also identified FoxM1 as a differentially-expressed gene in most solid tumors. Furthermore, overexpressed FoxM1 is correlated with the prognosis of cancer patients, as verified in a series of malignancies by Cox regression analysis. Thus, extensive studies have been conducted to explore the roles of FoxM1 in tumorigenesis, making it an attractive target for anticancer therapy. Several antitumor drugs have been reported to target or inhibit FoxM1 expression in different cancers, and down-regulation of FoxM1 also abrogates drug resistance in some cancer cell lines, highlighting a promising future for FoxM1 application in the clinic.

#FoxM1 #expression #prognosis #mechanism #drug resistance

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Xu, Xin-Sen

소속기관 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University