Antiproliferative Activity of the Methanolic Extract of Withania Somnifera Leaves from Faifa Mountains, Southwest Saudi Arabia, against Several Human Cancer Cell Lines

Alfaifi, Mohammad Yahya; Saleh, Kamel Ahmed; El-Boushnak, Mohammed Atallah; Elbehairi, Serag Eldin I; Alshehri, Mohammed Ali; Shati, Ali Abdullah

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자료유형: 학술저널

저자정보: Alfaifi, Mohammad Yahya (Biology Department, Faculty of Science, King Khalid University) Saleh, Kamel Ahmed (Biology Department, Faculty of Science, King Khalid University) El-Boushnak, Mohammed Atallah (Biology Department, Faculty of Science, King Khalid University) Elbehairi, Serag Eldin I (Biology Department, Faculty of Science, King Khalid University) Alshehri, Mohammed Ali (Biology Department, Faculty of Science, King Khalid University) Shati, Ali Abdullah (Biology Department, Faculty of Science, King Khalid University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제5호

발행연도: 2016.1

수록면: 2,723 - 2,726 (4page)

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Cancer represent one of the most serious health problems and major causes of death around the world. Many anticancer drugs in clinical use today are natural products or derived from natural sources. Withania somnifera (L.) Dunal is a small shrub widely distributed in many parts of the world including Saudi Arabia. The antiproliferative activities of the methanolic extract of W. somnifera leaves collected from Faifa mountains, southwest Saudi Arabia against MCF-7, HCT116 and HepH2 cell lines were investigated. The extract showed a strong antiproliferative activity against all cell lines with $IC_{50}$ values of 3.35, 2.19 and $1.89{\mu}g/ml$, respectively. Flow cytometry results showed that the extract arrested the cell cycle at S phase, and the increase in the caspase 3 activity suggested that the extract could induce cell apoptosis by a caspase mediated pathway. These results demonstrated that the methanolic extract of W. somnifera leaves collected from Faifa mountains has comparable strong antiproliferative activities to samples collected from different locations.

#Withania somnifera #MCF-7 #HCT116 #HepG2 #Caspase 3 #Antiproliferative

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