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학술저널
저자정보
Usuda, Katsuo (Department of Thoracic Surgery, Kanazawa Medical University) Maeda, Sumiko (Department of Thoracic Surgery, Kanazawa Medical University) Motono, Nozomu (Department of Thoracic Surgery, Kanazawa Medical University) Ueno, Masakatsu (Department of Thoracic Surgery, Kanazawa Medical University) Tanaka, Makoto (Department of Thoracic Surgery, Kanazawa Medical University) Machida, Yuichiro (Department of Thoracic Surgery, Kanazawa Medical University) Matoba, Munetaka (Department of Radiology, Kanazawa Medical University) Watanabe, Naoto (Department of Radiology, Kanazawa Medical University) Tonami, Hisao (Department of Radiology, Kanazawa Medical University) Ueda, Yoshimichi (Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University) Sagawa, Motoyasu (Department of Thoracic Surgery, Kanazawa Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제15호
발행연도
2015.1
수록면
6,401 - 6,406 (6page)

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Background: It is sometimes difficult to assess patients who have multiple hilar and mediastinal lymph nodes (MHMLN) with FDG accumulation in PET-CT. Since it is uncertain whether diffusion-weighted magnetic resonance imaging (DWI) is useful in the assessment of such patients, its diagnostic performance was assessed. Materials and Methods: Twenty-three patients who had three or more stations of hilar and mediastinal lymph nodes with SUVmax of 3 or more in PET-CT were included in this study. Results: For diagnosis of disease, there were 20 malignancies (lung cancers 17, malignant lymphomas 2 and metastatic lung tumor 1), and 3 benign cases (sarcoidosis 2 and benign disease 1). For diagnosis of lymph nodes, there were 7 malignancies (metastasis of lung cancer 7 and malignant lymphoma 1) and 16 benign lymphadenopathies (pneumoconiosis/silicosis 7, sarcoidosis 4, benign disease 4, and atypical lymphocyte infiltration 1). The ADC value ($1.57{\pm}0.29{\times}10^{-3}mm^2/sec$) of malignant MHMLN was significantly lower than that ($1.99{\pm}0.24{\times}10^{-3}mm^2/sec$) of benign MHMLN (P=0.0437). However, the SUVmax was not significantly higher ($10.0{\pm}7.34$ as compared to $6.38{\pm}4.31$) (P=0.15). The sensitivity (86%) by PET-CT was not significantly higher than that (71%) by DWI for malignant MHMLN (P=1.0). The specificity (100%) by DWI was significantly higher than that (31%) for benign MHMLN (P=0.0098). Furthermore, the accuracy (91%) with DWI was significantly higher than that (48%) with PET-CT for MHMLN (P=0.0129). Conclusions: Evaluation by DWI for patients with MHMLN with FDG accumulation is useful for distinguishing benign from malignant conditions.

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