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논문 기본 정보

자료유형
학술저널
저자정보
Siriwan Tangjitgamol (Navamindradhiraj University) Ekkasit Tharavichitkul (Chiang Mai University Chiang Mai) Chokaew Tovanabutra (Chonburi Cancer Hospital) Kanisa Rongsriyam (Faculty of Medicine Vajira Hospital) Tussawan Asakij (Lampang Cancer Hospital) Kannika Paengchit (Gynecologic Oncology section Lampang Cancer Hospital) Jirasak Sukhaboon (Radiation Oncology Section Lopburi Cancer Hospital) Somkit Penpattanagul (Radiation Oncology Section Udonthani Cancer Hospital) Apiradee Kridakara (Radiation Oncology Section Bhumibol Adulyadej Hospital) Jitti Hanprasertpong (Department of Obstetrics and Gynecology Prince of Songkla University) Kittisak Chomprasert (Radiation Oncology Section Chonburi Cancer Hospital) Sirentra Wanglikitkoon (Radiation Oncology Section Udonthani Cancer Hospital) Thiti Atjimakul (Department of Obstetrics and Gynecology Prince of Songkla University) Piyawan Pariyawateekul (Obstetrics and Gynecology Section Bhumibol Adulyadej Hospital) Kanyarat Katanyoo (Department of Radiology Faculty of Medicine Vajira Hospital) Prapai Tanprasert (Obstetrics and Gynecology Section Rajburi Hospital) Wanwipa Janweerachai (Radiation Oncology Section Rajburi Hospital) Duangjai Sangthawan (Department of Radiology Prince of Songkla University) Jakkapan Khunnarong (Faculty of Medicine Vajira Hospital) Taywin Chottetanaprasith (Radiation Oncology Section Ubonratchathani Cancer Hospital) Busaba Supawattanabodee (Department of Basic Sciences Faculty of Medicine Vajira Hospital) Prasert Lertsanguansinchai (Department of Radiology King Chulalongkorn Memorial Hospital) Jatupol Srisomboon (Department of Obstetrics and Gynecology Faculty of Medicine Chiang Mai University) Wanrudee Isaranuwatchai (Health Intervention and Technology Assessment Program) Vichan Lorvidhaya (Radiation Oncology Section Chonburi Cancer Hospital)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.30 No.4
발행연도
2019.1
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1 - 13 (13page)

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Objective: To compare response rate and survivals of locally advanced stage cervical cancer patients who had standard concurrent chemoradiation therapy (CCRT) alone to those who had adjuvant chemotherapy (ACT) after CCRT. Methods: Patients aged 18–70 years who had International Federation of Gynecology and Obstetrics stage IIB–IVA without para-aortic lymph node enlargement, Eastern Cooperative Oncology Group scores 0–2, and non-aggressive histopathology were randomized to have CCRT with weekly cisplatin followed by observation (arm A) or by ACT with paclitaxel plus carboplatin every 4 weeks for 3 cycles (arm B). Results: Data analysis of 259 patients showed no significant difference in complete responses at 4 months after treatment between arm A (n=129) and arm B (n=130): 94.1% vs. 87.0% (p=0.154) respectively. With the median follow-up of 27.4 months, 15.5% of patients in arm A and 10.8% in arm B experienced recurrences (p=0.123). There were no significant differences of overall or loco-regional failure. However, systemic recurrences were significantly lower in arm B than arm A: 5.4% vs. 10.1% (p=0.029). The 3-year progression-free survival (PFS) and 3-year overall survival (OS) of the patients in both arms were not significantly different. The hazard ratio of PFS and OS of arm B compared to arm A were 1.26 (95% CI=0.82–1.96; p=0.293) and 1.42 (95% CI=0.81–2.49; p=0.221) respectively. Conclusions: ACT with paclitaxel plus carboplatin after CCRT did not improve response rate and survival compared to CCRT alone. Only significant decrease of systemic recurrences with ACT was observed, but not overall or loco-regional failure. Trial Registration: ClinicalTrials.gov Identifier: NCT02036164Thai Clinical Trials Registry Identifier: TCTR 20140106001
#Uterine Cervical Neoplasm #Concurrent #Chemoradiotherapy #Adjuvant Chemotherapy

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참고문헌 (16)

참고문헌 신청
WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre) / Human papillomavirus and related cancers in World. Summary report 2010 / World Health Organization google schola Khuhaprema T / 2000 / Cancer in Thailand vol. IV, 1998–2000 / Ministry of Public Health and Ministry of Education google schola 2008 / Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials / J Clin Oncol 26:5802~5812 google schola Vrdoljak E / 2006 / Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy for women with locally advanced carcinoma of the uterine cervix--final results of a prospective phase II-study / Gynecol Oncol 103:494~499 google schola Domingo E / 2009 / Capecitabine-based chemoradiotherapy with adjuvant capecitabine for locally advanced squamous carcinoma of the uterine cervix : phase II results / Oncologist 14:828~834 google schola

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