Inhibition of NF-ĸB, Bcl-2 and COX-2 Gene Expression by an Extract of Eruca sativa Seeds during Rat Mammary Gland Carcinogenesis

Abdel-Rahman, Salah; Shaban, Nadia; Haggag, Amany; Awad, Doaa; Bassiouny, Ahmad; Talaat, Iman

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저자정보: Abdel-Rahman, Salah (Department of Nucleic Acid Research, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications) Shaban, Nadia (Department of Biochemistry, Faculty of Science, Alexandria University) Haggag, Amany (Department of Nucleic Acid Research, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications) Awad, Doaa (Department of Biochemistry, Faculty of Science, Alexandria University) Bassiouny, Ahmad (Department of Biochemistry, Faculty of Science, Alexandria University) Talaat, Iman (Department of Pathology, Faculty of Medicine, Alexandria University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제18호

발행연도: 2015.1

수록면: 8,411 - 8,418 (8page)

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The effect of Eruca sativa seed extract (SE) on nuclear factor kappa B (NF-${\kappa}B$), cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) gene expression levels was investigated in rat mammary gland carcinogenesis induced by 7,12 dimethylbenz(${\alpha}$)anthracene (DMBA). DMBA increased NF-${\kappa}B$, COX-2 and Bcl-2 gene expression levels and lipid peroxidation (LP), while, decreased glutathione-S-transferase (GST) and superoxide dismutase (SOD) activities and total antioxidant concentration (TAC) compared to the control group. After DMBA administration, SE treatment reduced NF-${\kappa}B$, COX-2 and Bcl-2 gene expression levels and LP. Hence, SE treatment reduced inflammation and cell proliferation, while increasing apoptosis, GST and SOD activities and TAC. Analysis revealed that SE has high concentrations of total flavonoids, triterpenoids, alkaloids and polyphenolic compounds such as gallic, chlorogenic, caffeic, 3,4-dicaffeoyl quinic, 3,5-dicaffeoyl quinic, tannic, cinnamic acids, catechin and phloridzin. These findings indicate that SE may be considered a promising natural product from cruciferous vegetables against breast cancer, especially given its high antioxidant properties.

#DMBA #breast cancer #Eruca sativa #NF- ${kappa}B$ #bcl-2 #COX-2 #qRT-PCR

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Abdel-Rahman, Salah

소속기관 Department of Nucleic Acid Research, Genetic Engineering and Biotechnology Research Institute, City