Expression of Cox-2 and Bcl-2 in Paget's Disease of the Breast

Alikanoglu, Arsenal Sezgin; Yildirim, Mustafa; Suren, Dinc; Tutus, Birsel; Kaya, Vildan; Topal, Cumhur Selcuk; Keser, Sevinc; Karadayi, Ayse Nimet; Kapucuoglu, Fatma Nilgun; Ayva, Sebnem; Gunduz, Seyda

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자료유형: 학술저널

저자정보: Alikanoglu, Arsenal Sezgin (Department of Pathology, Antalya Education and Research Hospital) Yildirim, Mustafa (Department of Medical Oncology, Ministry of Health Batman Regional Goverment Hospital) Suren, Dinc (Department of Medical Oncology, Ministry of Health Batman Regional Goverment Hospital) Tutus, Birsel (Department of Pathology, Ministry of Health Finike Regional Goverment Hospital) Kaya, Vildan (Department of Radiation Oncology, Suleyman Demirel University) Topal, Cumhur Selcuk (Department of Pathology, Umraniye Education and Research Hospital) Keser, Sevinc (Department of Pathology, Kartal Education and Research Hospital) Karadayi, Ayse Nimet (Department of Pathology, Kartal Education and Research Hospital) Kapucuoglu, Fatma Nilgun (Department of Pathology, Suleyman Demirel University) Ayva, Sebnem (Department of Pathology, Baskent University) Gunduz, Seyda (Department of Medical Oncology, Antalya Education and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 1,041 - 1,045 (5page)

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Background: Paget's disease (PD) is a rare form of intraepithelial adenocarcinoma that involves breast and extramammarian tissues. It is often associated with ductal carcinoma in situ and/or invasive ductal cancer. Molecular pathways that play a role in development of Paget's disease are stil unclear. Expression patterns of Cox-2 and bcl-2 were therefore assessed. Materials and Methods: Patients with a histopathological diagnosis of Paget's disease were included in this study. Patient files were analysed retrospectively. Results: Invasive cancer was diagnosed in 35 (76.1%) of the patients, 7 (15.2%) had ductal carcinoma in situ and 4 (8.7%) patients had no associated neoplasm. Twenty four (52.2%) patients showed COX-2 expression in Paget cells whereas no expression was seen in 22 (47.8%) patients. No relation was found between COX-2 expression and the lesion underlying Paget's disease (p=0.518). Bcl-2 expression in Paget cells was found positive in 12 (26.1%) and negative in 27 (58,7%) cases. There was no relation between Bcl-2 expression and the lesion accompanying Paget's disease (p=0.412). No relation was observed between COX-2 expression and Bcl-2 expression (p=0.389). Conclusions: In breast cancer, COX-2 expression is associated with poor prognostic factors. As COX-2 expression increases the tendency to metastasize also increases. In our study we found a significantly high COX-2 expression in Paget's disease of the breast. We suggest that COX-2 expression and inflammatory processes may play a role in pathogenesis of the Paget's disease of the breast.

#Paget's disease #breast cancer #COX-2 #Bcl-2 #inflammation

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