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학술저널
저자정보
Seo, Ji-Hyun (Department of Pediatrics, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine) Yeom, Jung Sook (Department of Pediatrics, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine) Youn, Hee-Shang (Department of Pediatrics, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine) Han, Tae-Hee (Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Inje University College of Medicine) Chung, Ju-Young (Department of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제58권 제3호
발행연도
2015.1
수록면
102 - 107 (6page)

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Purpose: Human parechovirus (HPeV) and enterovirus (EV) are causative agents of a sepsis-like illness in neonates and of infections of the central nervous system in young children. The objectives of this study were to assess the prevalence of HPeV3 and EV infection in young children with a sepsis-like illness or with meningitis in Jinju, Korea. Methods: Cerebrospinal fluid (CSF) samples were collected from 267 patients (age range, 1 day to 5 years) and assessed for HPeV and EV by performing reverse transcription polymerase chain reaction assay. Amplification products of the VP3/VP1 region of HPeV and of the VP1 region of EV were sequenced to identify the virus type. Results: HPeV and EV were detected in 3.4% and 7.5% of the total CSF samples assessed, respectively. The age distribution of EV-positive patients (median age, 1.4 months) had a significantly broader range than that of HPeV-positive patients (median age, 7.8 months). The peak seasons for HPeV and EV infection were spring and summer, respectively. The clinical symptoms for HPeV and EV infection were similar, and fever was the most common symptom. Pleocytosis was detected in 22.2% of HPeV-positive patients and 35.5% of EV-positive patients. The VP3/VP1 gene sequence of the nine Korean strains clustered most closely with the Japanese strain (AB759202). Conclusion: The data indicate that HPeV infection is predominant in young infants (<6 months) and that meningitis without pleocytosis was caused by both HPeV and EV infection in children.

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