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논문 기본 정보

자료유형
학술저널
저자정보
Youngseok Lee (Department of Biotechnology College of Life Sciences and Biotechnology Korea University) Jong-Hoon Kim (Department of Biotechnology College of Life Sciences and Biotechnology Korea University)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제28권 제4호
발행연도
2022.10
수록면
706 - 724 (19page)

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초록· 키워드

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Extracellular vesicles (EVs) are membrane-enclosed particles released from almost all cell types. EVs mediate intercellular communication by delivering their surface and luminal cargoes, including nucleic acids, proteins, and lipids, which reflect the pathophysiological conditions of their cellular origins. Hepatocytes and hepatic non-parenchymal cells utilize EVs to regulate a wide spectrum of biological events inside the liver and transfer them to distant organs through systemic circulation. The liver also receives EVs from multiple organs and integrates these extrahepatic signals that participate in pathophysiological processes. EVs have recently attracted growing attention for their crucial roles in maintaining and regulating hepatic homeostasis. This review summarizes the roles of EVs in intrahepatic and interorgan communications under different pathophysiological conditions of the liver, with a focus on chronic liver diseases including nonalcoholic steatohepatitis, alcoholic hepatitis, viral hepatitis, liver fibrosis, and hepatocellular carcinoma. This review also discusses recent progress for potential therapeutic applications of EVs by targeting or enhancing EV-mediated cellular communication for the treatment of liver diseases.

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