Acute Radiation Syndrome in an Irradiated Minipig Model for Patients with Radiation Exposure

Jang, Hyosun; Kim, Joong-sun; Shim, Sehwan; Jang, Won-seok; Lee, Sun-Joo; Myung, Jae Kyung; Lee, Seung-Sook; Park, Sunhoo

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자료유형: 학술저널

저자정보: Jang, Hyosun (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Kim, Joong-sun (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Shim, Sehwan (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Jang, Won-seok (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Lee, Sun-Joo (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Myung, Jae Kyung (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Lee, Seung-Sook (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Park, Sunhoo (Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences)

저널정보: 대한방사선방어학회 방사선방어학회지 방사선방어학회지 제42권 제3호

발행연도: 2017.1

수록면: 146 - 153 (8page)

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Background: Acute radiation syndrome (ARS) primarily refers to damage to the hematopoietic system, myeloid system, and gastrointestinal (GI) system caused by radiation exposure. Such damage progresses to become life-threatening. In particular, as the syndrome develops very rapidly-within several hours from radiation exposure-prompt and accurate diagnosis and treatment are needed, as is further research into appropriate diagnostic and treatment modalities. Materials and Methods: Minipigs, which display human-like properties, underwent whole-body irradiation at 2 or 4 Gy (doses causing hematopoietic ARS) or at higher doses of 7 or 12 Gy. Changes in the blood cells and clinical symptoms were analyzed and we performed a necropsy when the animals succumbed to ARS. Results and Discussion: The minipig irradiated with 2 Gy showed a decrease in white blood cells, including neutrophils, lymphocytes, and platelets in the early stages. However, the blood cell counts gradually increased and returned to normal values. The minipig irradiated with 4 Gy succumbed due to hematopoietic ARS. In contrast, the minipigs irradiated with 7 or 12 Gy exhibited clinical symptoms of combined GI damage and hematopoietic syndrome. Moreover, a characteristic pattern of platelet changes was observed in the 7 and 12 Gy irradiated minipigs. Conclusion: The changes in the platelet count caused by radiation exposure observed in minipigs, which are hematologically and pathohistologically similar to humans, suggest that they can be used as a novel diagnostic criterion.

#Radiation #Minipig #Blood #Bone marrow

참고문헌 (21)

참고문헌 신청

Dörr HD / 2006 / Appropriate radiation accident medical management: Necessity of extensive preparatory planning / Radiat. Environ. Biophys 45(4):237~244

Dörr H / 2011 / Acute radiation syndrome caused by accidental radiation exposure-therapeutic principles / BMC Medicine 9:126

Dainiak N. / 2002 / Hematologic consequences of exposure to ionizing radiation / Exp. Hematol 30(6):513~528

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Jang, Hyosun

소속기관 Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Scien