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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Joong-Sun (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Jang, Hyosun (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Bae, Min-Ji (Research Center, Dongnam Institute of Radiological & Medical Sciences) Shim, Sehwan (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Jang, Won-Seok (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Lee, Sun-Joo (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Park, Sunhoo (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences) Lee, Seung-Sook (Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences)
저널정보
대한방사선방어학회 방사선방어학회지 방사선방어학회지 제42권 제4호
발행연도
2017.1
수록면
189 - 196 (8page)

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Background: The effects of radiation on tissues vary depending on the radiation type. In this study, a minipig model was used to compare the effects of ${\beta}$-rays from $^{166}Ho$ and ${\gamma}$-rays from $^{60}Co$ on the skin. Materials and Methods: In this study, the detrimental effects of ${\beta}$- and ${\gamma}$-irradiation on the skin were assessed in minipigs. The histopathological changes in the skin from 1 to 12 weeks after exposure to 50 Gy of either ${\beta}$- (using $^{166}Ho$ patches) or ${\gamma}$- (using $^{60}Co$) irradiation were assessed. Results and Discussion: The skin irradiated by ${\beta}$-rays was shown to exhibit more severe skin injury than that irradiated by ${\gamma}$-rays at 1-3 weeks post-exposure; however, while the skin lesions caused by ${\beta}$-rays recovered after 8 weeks, the ${\gamma}$-irradiated skin lesions were not repaired after this time. The observed histopathological changes corresponded with gross appearance scores. Seven days post-irradiation, apoptotic cells in the basal layer were detected more frequently in ${\beta}$-irradiated skin than in ${\gamma}$-irradiated skin. The basal cell density and skin thickness gradually decreased until 4 weeks after ${\gamma}$- and ${\beta}$- irradiation. In ${\beta}$-irradiated skin lesions, and the density and thickness increased sharply back to control levels by 6-9 weeks. However, this was not the case in ${\gamma}$-irradiated skin lesions. In ${\gamma}$-irradiated skin, cyclooxygenase-2 (COX-2) was shown to be expressed in the epidermis, endothelial cells of vessels, and fibroblasts, while ${\beta}$-irradiated lesions exhibited COX-2 expression that was mostly limited to the epidermis. Conclusion: In this study, ${\beta}$-rays were shown to induce more severe skin injury than ${\gamma}$-rays; however, the ${\beta}$-rays-induced injury was largely repaired over time, while the ${\gamma}$-rays-induced injury was not repaired and instead progressed to necrosis. These findings reveal the differential effects of ${\gamma}$- and ${\beta}$-irradiation on skin and demonstrate the use of minipigs as a beneficial experimental model for studying irradiation-induced skin damage.
#Minipig #${beta}$-irradiation #${gamma}$-irradiation #Skin #COX-2

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