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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The dependence of cell survival on exposure dose and the duration of the liquidholding recovery (LHR) was obtained for diploid yeast cells irradiated with ionizing radiation of different linear energy transfer (LET) and recovering from radiation damage without and with various concentrations of cisplatin - the most widely used anticancer drug. The ability of yeast cells to recover from radiation damage was less effective after cell exposure to high-LET radiation, when cells were irradiated without drug. The increase in cisplatin concentration resulted in the disappearance of this difference whereas the fraction of irreversible damage was permanently enlarged independently of radiation quality. The probability of cell recovery was shown to be constant for various conditions of irradiation and recovery. A new mechanism of cisplatin action was suggested according with which the inhibition of cell recovery after exposure to ionizing radiations was completely explained by the production of irreversible damage.
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참고문헌 (13)
참고문헌 신청
Dale RG / 2009 / Why more needs to be known about RBE effects in modern radiotherapy / Appl. Radiat. Isot 67:387~392
Dasari S. / 2014 / Cisplatin in cancer therapy:molecular mechanisms of action / Eur. J. Pharmacol 740:364~378
Dasu A / 2008 / What is the clinically relevant relative biological effectiveness? A warning for fractionated treatments with high linear energy transfer / Int. J. Radiat. Oncol. Biol. Phys 70:867~874
Evstratova ES / 2016 / Influence of chemical inhibitors on cell recovery after exposure to different LET radiation / 2016 Autumn Meeting of the Korean Association for Radiation Protection
Hall EJ / 2012 / Radiobiology for the Radiologist / Lippimcott, Williams and Wilkins :576
Dasari S. / 2014 / Cisplatin in cancer therapy:molecular mechanisms of action / Eur. J. Pharmacol 740:364~378
Dasu A / 2008 / What is the clinically relevant relative biological effectiveness? A warning for fractionated treatments with high linear energy transfer / Int. J. Radiat. Oncol. Biol. Phys 70:867~874
Evstratova ES / 2016 / Influence of chemical inhibitors on cell recovery after exposure to different LET radiation / 2016 Autumn Meeting of the Korean Association for Radiation Protection
Hall EJ / 2012 / Radiobiology for the Radiologist / Lippimcott, Williams and Wilkins :576
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