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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제62권 제3호
- 발행연도
- 2019.1
- 수록면
- 265 - 273 (9page)
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This study aimed to evaluate the anti-atherosclerotic and anti-hypertensive effects of six different plant extracts using a N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced rat model of hypertension. All extracts were administered orally for six weeks. At the end of the study period blood pressure, blood flow, aortic histopathology, and hepatic endothelial nitric oxide synthase (eNOS) expression were measured. Subsequently, we also measured the levels of intracellular reactive oxygen species, nitric oxide (NO), and anti-inflammatory cytokines in vitro. Based on these screening results, we selected extracts of Cinnamomum cassia (C. cassia) and Salvia miltiorrhiza (S. miltiorrhiza) for further evaluation. C. cassia and S. miltiorrhiza extracts ameliorated hypertension and atherosclerosis in L-NAME-treated rats in a dose-dependent manner. In addition, a mixture of C. cassia and S. miltiorrhiza had an additive effect to reduce blood pressure, increase blood flow, and normalize aortic tissue. This mixture demonstrated anti-oxidative and anti-inflammatory activities in vitro. In conclusion, although further analysis of the therapeutic mechanism is required, the anti-hypertensive and anti-atherosclerotic effects of this mixture are likely mediated by increased eNOS expression, and its anti-oxidative and anti-inflammatory activities.
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참고문헌 (29)
참고문헌 신청
O´Flaherty M / 2012 / Potential cardiovascular mortality reductions with stricter food policies in the United Kingdom of Great Britain and Northern Ireland / Bull World Health Organ 90(7):522~531
Oparil S / 2008 / Hypertension / Nat Rev Dis Primers 4:18014
Liu WT / 2008 / Cardiovascular roles of nitric oxide : A review of insights from nitric oxide synthase gene disrupted mice / Cardiovasc Res 77(1):19~29
Wu J / 2014 / The Role of Oxidative Stress and Inflammation in Cardiovascular Aging / BioMed Research International 2014:1~13
Berkban T / 2015 / Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats / Nutrients 7:5265~5280
Oparil S / 2008 / Hypertension / Nat Rev Dis Primers 4:18014
Liu WT / 2008 / Cardiovascular roles of nitric oxide : A review of insights from nitric oxide synthase gene disrupted mice / Cardiovasc Res 77(1):19~29
Wu J / 2014 / The Role of Oxidative Stress and Inflammation in Cardiovascular Aging / BioMed Research International 2014:1~13
Berkban T / 2015 / Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats / Nutrients 7:5265~5280
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