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자료유형
학술저널
저자정보
Cheon, Myeong-Sook (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Yoon, Tae-Sook (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Yasukawa, Ken (College of Pharmacy, Nihon University) Yu, So-Yeon (College of Pharmacy, Nihon University) Kim, Seung-Ju (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Choi, Go-Ya (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Moon, Byeong-Cheol (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Lee, A-Yeong (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Choo, Byung-Kil (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) Kim, Ho-Kyoung (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제52권 제2호
발행연도
2009.1
수록면
157 - 162 (6page)

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The roots of both Aralia continentalis and Angelica biserrata, known as 'Dokwhal' in Korea, have been used widely as a traditional oriental medicine to treat inflammation and thrombosis. However, the pharmacological differences between A. continentalis and A. biserrata have not been fully established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts of A. continentalis (ACE) and A. biserrata (ABE) on the production of inflammatory mediators and secondary swelling from chemically induced ear edema. In RAW264.7 macrophages, both ACE and ABE significantly inhibited the release of nitric oxide, prostaglandin $E_2$, interlukin-lbeta, and tumor necrosis factor-alpha in a dose dependent manner. In addition, the swelling from TPA-induced edema in mouse ears was reduced by ACE and ABE. Overall, ACE showed stronger activities than ABE in vitro and in vivo. Our results indicate that A. continentalis roots possess stronger anti-inflammatory activity than A. biserrata roots.

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