Change of Extracellular Glutamate Level in Striatum during Deep Brain Stimulation of the Entopeduncular Nucleus in Rats

Lee, Hyun-ju; Sung, Jae Hoon; Hong, Jae Taek; Kim, Il Sup; Yang, Seung Ho; Cho, Chul Bum

추천

검색

자료유형: 학술저널

저자정보: Lee, Hyun-ju (Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University) Sung, Jae Hoon (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) Hong, Jae Taek (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) Kim, Il Sup (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) Yang, Seung Ho (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) Cho, Chul Bum (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea)

저널정보: 대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제62권 제2호

발행연도: 2019.1

수록면: 166 - 174 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective : Globus pallidus interna (GPi) is acknowledged as an essential treatment for advanced Parkinson's disease (PD). Nonetheless, the neurotransmitter study about its results is undiscovered. The goal of this research was to examine influences of entopeduncular nucleus (EPN) stimulation, identical to human GPi, in no-lesioned (NL) rat and 6-hydroxydopamine (6-HD)-lesioned rat on glutamate change in the striatum. Methods : Extracellular glutamate level changes in striatum of NL category, NL with deep brain stimulation (DBS) category, 6-HD category, and 6-HD with DBS category were examined using microdialysis and high-pressure liquid chromatography. Tyrosine hydroxylase (TH) immunoreactivities in substantia nigra and striatum of the four categories were also analyzed. Results : Extracellular glutamate levels in the striatum of NL with DBS category and 6-HD with DBS category were significantly increased by EPN stimulation compared to those in the NL category and 6-HD category. EPN stimulation had no significant effect on the expression of TH in NL or 6-HD category. Conclusion : Clinical results of GPi DBS are not only limited to direct inhibitory outflow to thalamus. They also include extensive alteration within basal ganglia.

#Entopeduncular nucleus #Glutamates #Deep brain stimulation #Parkinson disease

참고문헌 (29)

참고문헌 신청

Abosch A / 2003 / Stimulation of the subthalamic nucleus in Parkinson’s disease does not produce striatal dopamine release / Neurosurgery 53:1095~1102

Agnesi F / 2010 / Local glutamate release in the rat ventral lateral thalamus evoked by high-frequency stimulation / J Neural Eng 7:26009

Bar-Gad I / 2004 / Complex locking rather than complete cessation of neuronal activity in the globus pallidus of a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated primate in response to pallidal microstimulation / J Neurosci 24:7410~7419

Barnéoud P / 1995 / Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat / Neuroscience 67:837~848

Boulet S / 2006 / Subthalamic stimulation-induced forelimb dyskinesias are linked to an increase in glutamate levels in the substantia nigra pars reticulata / J Neurosci 26:10768~10776

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Lee, Hyun-ju

소속기관 Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee Uni

주요연구분야 의약학 > 약학 의약학 > 임상의학 > 신경외과학

논문수 2 이용수 0

Sung, Jae Hoon