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논문 기본 정보

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학술저널
저자정보
Kim, Hong Rye (Department of Neurosurgery, Konyang University Hospital, Konyang University School of Medicine) Lee, Jae Jun (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Jung-Il (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Nam, Do Hyun (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Suh, Yeon-Lim (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Seol, Ho Jun (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
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대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제59권 제1호
발행연도
2016.1
수록면
44 - 51 (8page)

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Objective : Malignant gliomas with neuronal marker expression (MGwNM) are rare and poorly characterized. Increasingly diverse types of MGwNM have been described and these reported cases underscore the dilemmas in the classification and diagnosis of those tumors. The aim of this study is to provide additional insights into MGwNM and present the clinicopathological features of 18 patients. Methods : We reviewed the medical records of 18 patients diagnosed as MGwNM at our institute between January 2006 and December 2012. Macroscopic total resection was performed in 11 patients (61%). We evaluated the methylation status of $O^6$-methylguanine-DNA methyltransferase (MGMT) and expression of isocitrate dehydrogenase 1 (IDH-1) in all cases, and deletions of 1p and 19q in available cases. Results : The estimated median overall survival was 21.2 months. The median progression-free survival was 6.3 months. Six patients (33%) had MGMT methylation but IDH1 mutation was found in only one patient (6%). Gene analysis for 1p19q performed in nine patients revealed no deletion in six, 19q deletion only in two, and 1p deletion only in one. The extent of resection was significantly correlated with progression free survival on both univariate analysis and multivariate analysis (p=0.002 and p=0.013, respectively). Conclusion : In this study, the overall survival of MGwNM was not superior to glioblastoma. The extent of resection has a significant prognostic impact on progression-free survival. Further studies of the prognostic factors related to chemo-radio therapy, similar to studies with glioblastoma, are mandatory to improve survival.
#Malignant gliomas #Neuronal marker #Methylation status of $O^6$-methylguanine-DNA methyltransferase #Expression of isocitrate dehydrogenase 1 #1p and 19q

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참고문헌 (23)

참고문헌 신청
Aouba A / 2010 / Uncomplicated neurosurgical resection of a malignant glioneuronal tumour under haemostatic cover of rFVIIa in a severe haemophilia patient with a high-titre inhibitor : a case report and literature review of rFVIIa use in major surgeries / Haemophilia 16:54~60 google schola Aryan HE / 2004 / Primary anaplastic glio-neuronal tumor of the pineal gland : a new type of pineal neoplasm? / J Clin Neurosci 11:163~165 google schola Balss J / 2008 / Analysis of the IDH1 codon 132 mutation in brain tumors / Acta Neuropathol 116:597~602 google schola Biernat W / 2007 / Glioneuronal-mesenchymal tumour with malignant transformation / Folia Neuropathol 45:140~143 google schola Brat DJ / 2008 / Surgical neuropathology update : a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition / Arch Pathol Lab Med 132:993~1007 google schola

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