Prognostic Factors Influencing Clinical Outcomes of Malignant Glioblastoma Multiforme: Clinical, Immunophenotypic, and Fluorescence in Situ Hybridization Findings for 1p19q in 816 Chinese Cases

Qin, Jun-Jie; Liu, Zhao-Xia; Wang, Jun-Mei; Du, Jiang; Xu, Li; Zeng, Chun; Han, Wu; Li, Zhi-Dong; Xie, Jian; Li, Gui-Lin

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자료유형: 학술저널

저자정보: Qin, Jun-Jie (Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University) Liu, Zhao-Xia (Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University) Wang, Jun-Mei (Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University) Du, Jiang (Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University) Xu, Li (Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University) Zeng, Chun (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute) Han, Wu (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute fo) Li, Zhi-Dong (Department of Neurosurgery, Beijing Ti) Xie, Jian Li, Gui-Lin

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 971 - 977 (7page)

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Malignant glioblastoma multiforme (GBM) is the most malignant brain tumor and despite recent advances in diagnostics and treatment prognosis remains poor. In this retrospective study, we assessed the clinical and radiological parameters, as well as fluorescence in situ hybridization (FISH) of 1p19q deletion, in a series of cases. A total of 816 patients with GBM who received surgery and radiation between January 2010 and May 2014 were included in this study. Kaplan-Meier survival analysis and Cox regression analysis were used to find the factors independently influencing patient progression free survival (PFS) and overall survival (OS). Age at diagnosis, preoperative Karnofsky Performance Scale (KPS) score, KPS score change at 2 weeks after operation, neurological deficit symptoms, tumor resection extent, maximal tumor diameter, involvement of eloquent cortex or deep structure, involvement of brain lobe, Ki-67 and MMP9 expression level and adjuvant chemotherapy were statistically significant factors (p<0.05) for both PFS and OS in the univariate analysis. Cox proportional hazards modeling revealed that age ${\leq}50$ years, preoperative KPS score ${\geq}80$, KPS score change after operation ${\geq}0$, involvement of single frontal lobe, deep structure involvement, low Ki-67 and MMP9 expression and adjuvant chemotherapy were independent favorable factors (p<0.05) for patient clinical outcomes.

#Malignant glioblastoma multiform #prognostic factor #FISH of 1p19q #immunohistochemistry

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