지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 101 - 106 (6page)
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초록· 키워드
오류제보하기
Objective : The aim of this study was to explore the immunity in rats transplanted with adipose-derived mesenchymal stem cells (ADSCs) and acellular nerve (ACN) for repairing sciatic nerve defects. Methods : ADSCs were isolated from the adipose tissues of Wistar rats. Sprague-Dawley rats were used to establish a sciatic nerve defect model and then divided into four groups, according to the following methods : Group A, allogenic nerve graft; Group B, allograft with ACN; Group C, allograft ADSCs+ACN, and Group D, nerve autograft. Results : At the day before transplantation and 3, 7, 14, and 28 days after transplantation, orbital venous blood of the Sprague-Dawley rats in each group was collected to detect the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets using flow cytometry and to determine the serum concentration of interleukin-2 (IL-2), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and $interferon-{\gamma}$ ($IFN-{\gamma}$) using enzyme-linked immunosorbent assay (ELISA). At each postoperative time point, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ in group C were all near to those in group B and group D, in which no statistically significant difference was observed. As compared with group A, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ were significantly reduced in group C (p<0.05). Conclusion : The artificial nerve established with ADSCs and ACN has no obvious allograft rejection for repairing rat nerve defects.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Bain JR. / 1988 / The peripheral nerve allograft : an assessment of regeneration across nerve allografts in rats immunosuppressed with cyclosporin A / Plast Reconstr Surg 82:1052~1066
Comoli P. / 2008 / Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation / Nephrol Dial Transplant 23:1196~1202
de Ruiter GC. / 2009 / Nerve tubes for peripheral nerve repair / Neurosurg Clin N Am 20:91~105
Gao X. / 2013 / The role of peripheral nerve ECM components in the tissue engineering nerve construction / Rev Neurosci 24:443~453
Hong SJ. / 2010 / Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair / Curr Opin Organ Transplant 15:86~91
Comoli P. / 2008 / Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation / Nephrol Dial Transplant 23:1196~1202
de Ruiter GC. / 2009 / Nerve tubes for peripheral nerve repair / Neurosurg Clin N Am 20:91~105
Gao X. / 2013 / The role of peripheral nerve ECM components in the tissue engineering nerve construction / Rev Neurosci 24:443~453
Hong SJ. / 2010 / Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair / Curr Opin Organ Transplant 15:86~91
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