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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. Methods : Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKRS and at 1 week, 1 month, 3 month and 6 month visits. Plasma VEGF levels were measured using commercially available enzyme-linked immunosorbent assay. For controls, peripheral blood samples were obtained from 20 healthy volunteers. Results : The mean plasma VEGF level (29.6 pg/mL) in patients with meningiomas before GKRS was significantly lower than that of the control group (62.4 pg/mL, p=0.019). At 1 week after GKRS, the mean plasma VEGF levels decreased to 23.4 pg/mL, and dropped to 13.9 pg/mL at 1 month, 14.8 pg/mL at 3 months, then increased to 27.7 pg/mL at 6 months. Two patients (14.3%) with peritumoral edema (PTE) showed a level of VEGF 6 months after GKRS higher than their preradiosurgical level. There was no significant association found in an analysis of correlation between PTE and tumor size, marginal dose, age, and sex. Conclusion : Our study is first in demonstrating changes of plasma VEGF after stereotactic radiosurgery (SRS) for meningioma. This study may provide a stimulus for more work related to whether measurement of plasma level has a correlation with tumor response after SRS for meningioma.
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참고문헌 (18)
참고문헌 신청
Chang JH. / 2003 / Complications after gamma knife radiosurgery for benign meningiomas / J Neurol Neurosurg Psychiatry 74:226~230
Ganz JC. / 1996 / Radiation-induced edema after Gamma Knife treatment for meningiomas / Stereotact Funct Neurosurg 66 Suppl 1:129~133
Ilhan A. / 2009 / Angiogenic factors in plasma of brain tumour patients / Anticancer Res 29:731~736
Kan P. / 2007 / Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its development / J Neurooncol 83:33~38
Kim GH. / 2008 / Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformations / Stroke 39:2274~2279
Ganz JC. / 1996 / Radiation-induced edema after Gamma Knife treatment for meningiomas / Stereotact Funct Neurosurg 66 Suppl 1:129~133
Ilhan A. / 2009 / Angiogenic factors in plasma of brain tumour patients / Anticancer Res 29:731~736
Kan P. / 2007 / Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its development / J Neurooncol 83:33~38
Kim GH. / 2008 / Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformations / Stroke 39:2274~2279
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