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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 540 - 552 (13page)
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To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane in hepatocellular carcinoma cell HepG2. The SR-FTIR spectra observed a similar pattern vis-a-vis the biomolecular alteration amongst the ITCs-treated cells suggesting a similar mode of action. All of the ITCs in this study cause cancer cell death through both apoptosis and necrosis in concentration dependent manner ($20-80{\mu}M$). We found no interactions of any of the ITCs studied with DNA. Notwithstanding, all of the ITCs studied increased intracellular reactive oxygen species (ROS) and suppressed tubulin polymerization, which led to cell-cycle arrest in the S and $G_2/M$ phase. Alyssin possessed the most potent anticancer ability; possibly due to its ability to increase intracellular ROS rather than tubulin depolymerization. Nevertheless, the structural influence of alkyl chain length on anticancer capabilities of ITCs remains inconclusive. The results of this study indicate an optional, potent ITC (viz., alyssin) because of its underlying mechanisms against hepatic cancer. As a consequence, further selection and development of effective chemotherapeutic ITCs is recommended.
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참고문헌 (58)
참고문헌 신청
Abassi Joozdani, F / 2015 / Interaction of sulforaphane with DNA and RNA / PLoS ONE 10:e0127541
Agarwal, S / 2013 / Spectroscopic studies of the effects of anticancer drug mitoxantrone interaction with calf-thymus DNA / J. Photochem. Photobiol. B Biol 120:177~182
Al-Qenaei, A / 2014 / Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide / Free Radic. Biol. Med 68:87~100
Angelino, D / 2014 / Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates : focus on glucoraphanin / J. Funct. Foods 7:67~76
Azarenko, O / 2014 / Erucin, the major isothiocyanate in arugula(Eruca sativa), inhibits proliferation of MCF7 tumor cells by suppressing microtubule dynamics / PLoS ONE 9:e100599
Agarwal, S / 2013 / Spectroscopic studies of the effects of anticancer drug mitoxantrone interaction with calf-thymus DNA / J. Photochem. Photobiol. B Biol 120:177~182
Al-Qenaei, A / 2014 / Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide / Free Radic. Biol. Med 68:87~100
Angelino, D / 2014 / Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates : focus on glucoraphanin / J. Funct. Foods 7:67~76
Azarenko, O / 2014 / Erucin, the major isothiocyanate in arugula(Eruca sativa), inhibits proliferation of MCF7 tumor cells by suppressing microtubule dynamics / PLoS ONE 9:e100599
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