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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 282 - 288 (7page)
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Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key protein for bacterial cell division and a structural homologue of eukaryotic tubulin. Both tubulin and FtsZ contain a GTPbinding domain, have GTPase activity, assemble into protofilaments, two-dimensional sheets, and protofilament rings, and share substantial structural identities. Accordingly, we hypothesized that viriditoxin may inhibit eukaryotic cell division by inhibiting tubulin polymerization as in the case of bacterial FtsZ inhibition. Docking simulation of viriditoxin to β-tubulin indicated that it binds to the paclitaxel-binding domain and makes hydrogen bonds with Thr276 and Gly370 in the same manner as paclitaxel. Viriditoxin suppressed growth of A549 human lung cancer cells, and inhibited cell division with G2/M cell cycle arrest, leading to apoptotic cell death.
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참고문헌 (19)
참고문헌 신청
Juan Liu / 2013 / Viriditoxin, from a Jellyfish-derived Fungus, is Antibiotic to Fish Pathogens / Natural Product Sciences 19(1):61~65
Wong, D. T / 1976 / Biochem. Biophys. Res. Commun 71:332~338
Löwe, J / 1998 / Nature 391:203~206
Tian, W / 2012 / Pharmazie 67:811~816
Erickson, H. P / 1995 / Cell 80:367~370
Wong, D. T / 1976 / Biochem. Biophys. Res. Commun 71:332~338
Löwe, J / 1998 / Nature 391:203~206
Tian, W / 2012 / Pharmazie 67:811~816
Erickson, H. P / 1995 / Cell 80:367~370
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