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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 62 - 66 (5page)
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Amygdalin, D-mandelonitrile-${\beta}$-D-glucoside-6-${\beta}$-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor agent against breast cancer cells is not clear. The present study aimed to investigate the effect of amygdalin on the proliferation of human breast cancer cells. Here, we show that amygdalin exerted cytotoxic activities on estrogen receptors (ER)-positive MCF7 cells, and MDA-MB-231 and Hs578T triple-negative breast cancer (TNBC) cells. Amygdalin induced apoptosis of Hs578T TNBC cells. Amygdalin downregulated B-cell lymphoma 2 (Bcl-2), upregulated Bcl-2-associated X protein (Bax), activated of caspase-3 and cleaved poly ADP-ribose polymerase (PARP). Amygdalin activated a pro-apoptotic signaling molecule p38 mitogen-activated protein kinases (p38 MAPK) in Hs578T cells. Treatment of amygdalin significantly inhibited the adhesion of Hs578T cells, in which integrin ${\alpha}5$ may be involved. Taken together, this study demonstrates that amygdalin induces apoptosis and inhibits adhesion of breast cancer cells. The results suggest a potential application of amygdalin as a chemopreventive agent to prevent or alleviate progression of breast cancer, especially TNBC.
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참고문헌 (34)
참고문헌 신청
Albelda, S. M / 1993 / Role of integrins and other cell adhesion molecules in tumor progression and metastasis / Lab. Invest 68:4~17
Alizadeh, A. M / 2014 / Metastasis review: from bench to bedside / Tumour Biol 35:8483~8523
Bendas, G / 2012 / Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins / Int. J. Cell Biol 2012:676~731
Chang, H. K / 2006 / Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells / Biol. Pharm. Bull 29:1597~1602
Chen, Y / 2013 / Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells / Immunopharmacol. Immunotoxicol 35:43~51
Alizadeh, A. M / 2014 / Metastasis review: from bench to bedside / Tumour Biol 35:8483~8523
Bendas, G / 2012 / Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins / Int. J. Cell Biol 2012:676~731
Chang, H. K / 2006 / Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells / Biol. Pharm. Bull 29:1597~1602
Chen, Y / 2013 / Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells / Immunopharmacol. Immunotoxicol 35:43~51
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