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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 67 - 74 (8page)
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초록· 키워드
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In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-${\beta}$-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-$1{\beta}$-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Agbabiaka, T. B / 2008 / Pelargonium sidoides for acute bronchitis: A systematic review and meta-analysis / Phytomedicine 15:378~385
Al-Kassimi, F. A / 2013 / A challenge to the seven widely believed concepts of COPD / Int. J. Chron. Obstruct. Pulmon. Dis 8:21~30
Bae, K / 2000 / The medicinal plants of Korea / Kyo-Hak Pub. Co :360~361
Barnes, P. J / 2014 / Cellular and molecular mechanisms of chronic obstructive pulmonary disease / Clin. Chest Med 35:71~86
Xing Fu Cai / 2004 / Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum / Archives of Pharmacal Research 27(7):738~741
Al-Kassimi, F. A / 2013 / A challenge to the seven widely believed concepts of COPD / Int. J. Chron. Obstruct. Pulmon. Dis 8:21~30
Bae, K / 2000 / The medicinal plants of Korea / Kyo-Hak Pub. Co :360~361
Barnes, P. J / 2014 / Cellular and molecular mechanisms of chronic obstructive pulmonary disease / Clin. Chest Med 35:71~86
Xing Fu Cai / 2004 / Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum / Archives of Pharmacal Research 27(7):738~741
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