지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 15 - 23 (9page)
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초록· 키워드
오류제보하기
Acanthopanax divaricatus (Siebold & Zucc.) Seem. var. albeofructus (ADA), a traditional medical herb, has been used to treat arthritis and muscular injury, to strengthen muscle and bone, and to get vital energy. However, information regarding its toxicity is limited. ADA was administered by oral gavage to groups of rats at doses of 0 (control), 1,000, 1,500, 2,000, 2,500, and 3,000 mg/kg five times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, organ weights, necropsy, histopathological finding, vaginal cytology, and sperm morphology were compared between control and ADA-treated groups. Salivation was intermittently observed in both sexes receiving 2,500 and 3,000 mg/kg directly after dosing. Absolute liver weights increased in females receiving 2,000, 2,500, and 3,000 mg/kg ADA (P < 0.05, P < 0.01, and P < 0.01, respectively) and so did the relative liver weights (P < 0.001). Salivation and increased liver weight were ADA-related changes but not considered to be adverse effects. Salivation was intermittent and transient, and the liver weight increase was minor and not accompanied by other changes such as hepatic morphological or functional alterations. The noobserved-adverse-effect-level was determined to be at least 3,000 mg/kg in both sexes of rats.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Yook, C.S / 1996 / Chemical components of Acanthopanax divaricatus and anticancer effect in leaves / Yakhakhoe Chi 40:251~261
Kim, J.-H / 1981 / Studies on the chemical constituents of Acanthopanax chiisanensis Nakai roots / Arch. Pharm. Res 4:59~62
Takasugi, N / 1985 / Effect of Eleutherococcus senticosus and its components on rectal temperature, body and grip tones, motor coordination, and exploratory and spontaneous movements in acute stressed mice / Shoyakugaku Zasshi 39:232~237
Foster, S / 1992 / Herbal emissaries: bringing Chinese herbs to the West: a guide to gardening, herbal wisdom, and well-being / Healing arts press
Yamazaki, T / 2006 / Anti-inflammatory effects of eleutheroside E from Acanthopanax senticosus / Tissue Cult. Res. Commun 25:137~145
Kim, J.-H / 1981 / Studies on the chemical constituents of Acanthopanax chiisanensis Nakai roots / Arch. Pharm. Res 4:59~62
Takasugi, N / 1985 / Effect of Eleutherococcus senticosus and its components on rectal temperature, body and grip tones, motor coordination, and exploratory and spontaneous movements in acute stressed mice / Shoyakugaku Zasshi 39:232~237
Foster, S / 1992 / Herbal emissaries: bringing Chinese herbs to the West: a guide to gardening, herbal wisdom, and well-being / Healing arts press
Yamazaki, T / 2006 / Anti-inflammatory effects of eleutheroside E from Acanthopanax senticosus / Tissue Cult. Res. Commun 25:137~145
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UCI(KEPA) : I410-ECN-0101-2017-513-002054347