지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 101 - 108 (8page)
이용수
초록· 키워드
오류제보하기
G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Ahn, K. H. / 2010 / Hydrophobic residues in helix 8 of cannabinoid receptor 1 are critical for structural and functional properties / Biochemistry 49:502~511
Ballesteros, J. A. / 1995 / [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors / Methods Neurosci. 25:366~428
Boutet, E. / 2016 / Uni-ProtKB/Swiss-Prot, the manually annotated section of the UniProt KnowledgeBase: How to use the entry view / Methods Mol. Biol. 1374:23~54
Cho, D. I. / 2006 / Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine $D_2$ and $D_4$ receptors / Biochem. Biophys. Res. Commun. 350:634~640
천경수 / 2015 / EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells / Biomolecules & Therapeutics 23(6):539~548
Ballesteros, J. A. / 1995 / [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors / Methods Neurosci. 25:366~428
Boutet, E. / 2016 / Uni-ProtKB/Swiss-Prot, the manually annotated section of the UniProt KnowledgeBase: How to use the entry view / Methods Mol. Biol. 1374:23~54
Cho, D. I. / 2006 / Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine
천경수 / 2015 / EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells / Biomolecules & Therapeutics 23(6):539~548
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Molecular Signature That Determines the Acute Tolerance of G Protein-Coupled Receptors
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Analysis of CCR2 splice variant expression patterns and functional properties
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Pro-Inflammatory Role of S1P<sub>3</sub> in Macrophages
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Role of Helix 8 in Dopamine Receptor Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Calcium Signaling of Lysophosphatidylethanolamine through LPA<sub>1</sub> in Human SH-SY5Y Neuroblastoma Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Pathogen metabolite-odorant receptor interactions shape the pathogen-brain axis
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
Endocrinology and Metabolism
2021 .01
-
Human CD8+ T-Cell Populations That Express Natural Killer Receptors
Immune Network
2023 .02
-
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Functional characterization of CXCR3 splicing variants and their ligands
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Roles of Dopamine D<sub>2</sub> Receptor Subregions in Interactions with β-Arrestin2
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Progranulin and a Five Transmembrane Domain-Containing Receptor-Like Protein are the Key Components in Receptor Activator of Nuclear Factor Κb (RANK)-Dependent Formation of Multinucleated Osteoclasts
대한체질인류학회 학술대회 연제 초록
2015 .05
-
Molecular Genetics of von Willebrand Disease in Korean Patients: Novel Variants and Limited Diagnostic Utility of Multiplex Ligation-Dependent Probe Amplification Analyses
Annals of Laboratory Medicine
2019 .01
-
Structural Characteristics of Seven IL-32 Variants
Immune Network
2019 .04
-
Conceptual Progress for the Improvements in the Selectivity and Efficacy of G Protein-Coupled Receptor Therapeutics: An Overview
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0