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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 57 - 68 (12page)
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Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have been discovered via conventional bulk analysis techniques the increasing availability of structural and evolutionary data are facilitating change to rational, targeted drug design. This article discusses the appeal of neuropeptide-7TMR systems as drug targets and provides an overview of concepts in the evolution of vertebrate genomes and gene families. Subsequently, methods that use evolutionary concepts and comparative analysis techniques to aid in gene discovery, gene function identification, and novel drug design are provided along with case study examples.
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참고문헌 (80)
참고문헌 신청
Abi-Rached, L. / 2002 / Evidence of en bloc duplication in vertebrate genomes / Nat. Genet 31:100~105
Ahmad, R. / 2015 / Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand / Br. J. Pharmacol 172:3212~3228
Amemiya, C. T. / 2010 / Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome / Proc. Natl. Acad. Sci. U.S.A 107:3622~3627
Amores, A. / 2011 / Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication / Genetics 188:799~808
Assis, R. / 2013 / Neofunctionalization of young duplicate genes in Drosophila / Proc. Natl. Acad. Sci. U.S.A 110:17409~17414
Ahmad, R. / 2015 / Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand / Br. J. Pharmacol 172:3212~3228
Amemiya, C. T. / 2010 / Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome / Proc. Natl. Acad. Sci. U.S.A 107:3622~3627
Amores, A. / 2011 / Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication / Genetics 188:799~808
Assis, R. / 2013 / Neofunctionalization of young duplicate genes in Drosophila / Proc. Natl. Acad. Sci. U.S.A 110:17409~17414
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