메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Jeon, Se-Jin (Department of Pharmacology, College of Pharmacy and research Institute of Pharmaceutical Sciences, Seoul National University) Kwon, Kyung-Ja (Center for Geriatric Neuroscience Research, IBST and School of Medicine, Konkuk University) Shin, Sun-Mi (Department of Pharmacology, College of Pharmacy and research Institute of Pharmaceutical Sciences, Seoul National University) Lee, Sung-Hoon (Department of Pharmacology, College of Pharmacy and research Institute of Pharmaceutical Sciences, Seoul National University) Rhee, So-Young (Department of Pharmacology, College of Pharmacy and research Institute of Pharmaceutical Sciences, Seoul National University) Han, Seol-Heui (Center for Geriatric Neuroscience Research, IBST and School of Medicine, Konkuk University) Lee, Jong-Min (Center for Geriatric Neuroscience Research, IBST and School of Medicine, Konkuk University) Kim, Han-Young (Center for Geriatric Neuroscience Research, IBST and School of Medicine, Konkuk University) Cheong, Jae-Hoon (Department of Pharmacy, Sahmyook University) Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung) Min, Byung-Sun Ko, Kwang-Ho Shin, Chan-Young
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제17권 제1호
발행연도
2009.1
수록면
70 - 78 (9page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Coptis japonica (C. japonica) is a perennial medicinal plant that has anti-inflammatory activity. C. japonica contains numerous biologically active alkaloids including berberine, palmatine, epi-berberine, and coptisine. The most well-known anti-inflammatory principal in C. japonica is berberine. For example, berberine has been implicated in the inhibition of iNOS induction by cytokines in microglial cells. However, the efficacies of other alkaloids components on microglial activation were not investigated yet. In this study, we investigated the effects of three alkaloids (palmatine, epi-berberine and coptisine) from C. japonica on lipopolysaccharide (LPS)-induced microglial activation. BV2 microglial cells were immunostimulated with LPS and then the production of several inflammatory mediators such as nitric oxide (NO), reactive oxygen species (ROS) and matrix metalloproteinase-9 (MMP-9) were examined as well as the phosphorylation status of Erk1/2 mitogen activated protein kinase (MAPK). Palmatine and to a lesser extent epi-berberine and coptisine, significantly reduced the release of NO, which was mediated by the inhibition of LPS-stimulated mRNA and protein induction of inducible nitric oxide synthase (iNOS) from BV2 microglia. In addition to NO, palmatine inhibited MMP-9 enzymatic activity and mRNA induction by LPS. Palmatine also inhibited the increase in the LPS-induced MMP-9 promoter activity determined by MMP-9 promoter luciferase reporter assay. LPS stimulation increased Erk1/2 phosphorylation in BV2 cells and these alkaloids inhibited the LPS-induced phosphorylation of Erk1/2. The anti-inflammatory effect of palmatine in LPS-stimulated microglia may suggest the potential use of the alkaloids in the modulation of neuroinflammatory responses, which might be important in the pathophysiological events of several neurological diseases including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD) and stroke.
#Microglia #Coptis japonica #Nitric oxide #NO) #Inducible nitric oxide synthase #iNOS) #Matrixmetalloproteinase-9 #MMP-9)

목차

등록된 정보가 없습니다.

참고문헌 (40)

참고문헌 신청
Andjelkovic, A. V. / 1998 / Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study / Brain Research 814:13~25 google schola Asahi, M. / 2001 / Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia / J. Neurosci 21:7724~7732 google schola Bellosta, S. / 2003 / Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae) / Cell Mol. Life Sci 60:1440~1448 google schola Bozdagi, O. / 2007 / In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity / J. Neurophysiol 98:334~344 google schola Brown, G. C. / 2007 / Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase / Biochemical Society Transactions 35:1119~1121 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0