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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 351 - 355 (5page)
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Prodigiosin was isolated from marine bacteria Hahella chejuensis which has been recently discovered from Marado, Cheju Island, Republic of Korea. Immunosuppressive properties have been reported for prodigiosin members such as undecylprodigiosin, metacycloprodigiosin, prodigiosin, and its synthetic analogue PNU156804 (PNU). However, the effect of this agent on the function of macrophage and splenocyte has not been characterized in detail. In the present study, we examined the effects of prodigiosin for its ability to alter the function of murine macrophage and NK cell, and the proliferation of splenocytes. When thioglycollate-elicited macrophages pre-exposed to prodigiosin (1-50 ng/ml) were stimulated with LPS/IFN-$\gamma$, pretreatment with prodigiosin resulted in the inhibition of tumoricidal activity of macrophage in a concentration-dependent manner. Tumoricidal activity of NK cell was also inhibited by prodigiosin. Moreover, we found that prodigiosin was able to cause a dose-dependent inhibition of murine lymphocyte responsiveness to Con A and LPS although T-mitogenic response was the more sensitive one. Taken together, the present results point out that prodigiosin has a suppressive effect on the mitogen-induced proliferation of murine lymphocytes and the function of macrophage and NK cell.
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참고문헌 (16)
참고문헌 신청
Adams, D. O / 1984 / The cell biology of macrophage activation / Annu. Rev. Immunol 2:283~318
Bae,S.Y. / 2006 / Activation of murine peritoneal macrophages by sulfated exopolysaccharide from marine microalga Gyrodinium impudicum (strain KG03): involvement of the NF-κB and JNK pathway / Int. Immunopharmacol 6:473~484
Ding, A. H / 1988 / Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production / J. Immunol 141:2407~2412
Hahn, H / 1981 / The role of cell-mediated immunity in bacterial infections / Rev. Infect. Dis 3:1221~1250
Herberman, R. B / 1985 / Mechanisms of cytotoxicity by NK cells / Academic Press
Bae,S.Y. / 2006 / Activation of murine peritoneal macrophages by sulfated exopolysaccharide from marine microalga Gyrodinium impudicum (strain KG03): involvement of the NF-κB and JNK pathway / Int. Immunopharmacol 6:473~484
Ding, A. H / 1988 / Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production / J. Immunol 141:2407~2412
Hahn, H / 1981 / The role of cell-mediated immunity in bacterial infections / Rev. Infect. Dis 3:1221~1250
Herberman, R. B / 1985 / Mechanisms of cytotoxicity by NK cells / Academic Press
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