메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Shin, Un Chol (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Jung, Ki-Hye (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Lee, Ji Woong (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Lee, Kyo Chul (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Lee, Yong Jin (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Park, Ji-Ae (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Kim, Jung Young (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Kang, Joo Hyun (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) An, Gwang Il (Division of RI convergence research, Korea Institute of Radiological and Medical Sciences) Ryu, Young Hoon (Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) Choi, Jae Yong (Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei Unive) Kim, Kyeong Min
저널정보
대한방사성의약품학회 대한방사성의약품학회지 대한방사성의약품학회지 제2권 제2호
발행연도
2016.1
수록면
118 - 122 (5page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Integrin ${\alpha}_v{\beta}_3$ plays an important role in the tumor metastases and angiogenesis. Arginine-glycine-aspartate (RGD) peptide motif binds to the integrin ${\alpha}_v{\beta}_3$. General $^{68}Ga$-labeled cyclic RGD peptides was rapidly eliminated from the circulatory system by renal excretion because of its hydrophilic property. The purpose of this study was to develop a novel $^{68}Ga$-labeled cyclic RGD peptides, which could acquire enhanced PET tumor images with improved pharmacokinetics by adopting biphenyl group between chelator and RGD peptides. $^{68}Ga$-DOTA-2P-c(RGDyK) was demonstrated a 12% higher lipophilicity level than $^{68}Ga$-DOTA-c(RGDyK) as a reference compound. In the animal PET, $^{68}Ga$-DOTA-2P-c(RGDyK) represented relatively lower blood-clearance, and an increased signal to noise ratio compared to $^{68}Ga$-DOTA-c(RGDyK). From these perspective, $^{68}Ga$-DOTA-2P-c(RGDyK) could be a good candidate for in integrin ${\alpha}_v{\beta}_3$-expressed tumor imaging.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0