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논문 기본 정보

자료유형
학술저널
저자정보
Jung, Joo-Young (Biomedical Engineering and Research Institute, Catholic University of Korea College of Medicine) Cheon, Gi Jeong (Radiopharmaceutical Science Laboratory, Department of Nuclear Medicine, Seoul National University College of Medicine) Lee, Yun-Sang (Radiopharmaceutical Science Laboratory, Department of Nuclear Medicine, Seoul National University College of Medicine) Ha, Seunggyun (Radiopharmaceutical Science Laboratory, Department of Nuclear Medicine, Seoul National University College of Medicine) Chae, Mi-Hye (Department of Nuclear Medicine, Sung Ae General Hospital) Chung, Yong-An (Department of Nuclear Medicine, Catholic University of Korea College of Medicine) Yoon, Do Kyun (Biomedical Engineering and Research Institute, Catholic University of Korea College of Medicine) Bahk, Yong-Whee (Department of Nuclear Medicine, Sung Ae General Hospital)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제50권 제3호
발행연도
2016.1
수록면
207 - 212 (6page)

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Purpose Currently, traumatic bone diseases are diagnosed by assessing the micro $^{99m}Tc$-hydroxymethylene diphosphonate (HDP) uptake in injured trabeculae with ongoing osteoneogenesis demonstrated by gamma correction pinhole scan (GCPS). However, the mathematic size quantification of micro-uptake is not yet available. We designed and performed this phantom-based study to set up an in-vitro model of the mathematical calculation of micro-uptake by the pixelized measurement. Methods The micro $^{99m}Tc$-HDP deposits used in this study were spontaneously formed both in a large standard flood and small house-made dish phantoms. The processing was as follows: first, phantoms were flooded with distilled water and $^{99m}Tc$-HDP was therein injected to induce micro $^{99m}Tc$-HDP deposition; second, the deposits were scanned using parallel-hole and pinhole collimator to generally survey $^{99m}Tc$-HDP deposition pattern; and third, the scans underwent gamma correction (GC) to discern individual deposits for size measurement. Results In original $na{\ddot{i}}ve$ scans, tracer distribution was simply nebulous in appearance and, hence, could not be measured. Impressively, however, GCPS could discern individual micro deposits so that they were calculated by pixelized measurement. Phantoms naturally formed micro $^{99m}Tc$-HDP deposits that are analogous to $^{99m}Tc$-HDP uptake on in-vivo bone scan. The smallest one we measured was 0.414 mm. Flooded phantoms and therein injected $^{99m}Tc$-HDP form nebulous micro $^{99m}Tc$-HDP deposits that are rendered discernible by GCPB and precisely calculable using pixelized measurement. Conclusions This method can be used for precise quantitative and qualitative diagnosis of bone and joint diseases at the trabecular level.

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