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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 109 - 115 (7page)
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초록· 키워드
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Objective : Herbal medicinal mixture (JMB) are consisted of Caryophylli Flos, Aucklandiae Radix, and Angelicae Dahuricae Radix. Each of these herbal medicines has studied on anti-aging effect in vitro. So this study was conducted to investigate efficacy and potency of JMB extract on dermal anti-aging and whitening. Methods : The JMB was extracted at room temperature by 80% ethanol. Collagenase and elastase inhibition activity in JMB ethanol extract were determined at 10, 50, 100, 500, 1000 mg/ml concentrations by colorimetric method. The toxic range of JMB ethanol extract was evaluated using MTT assay. Also, The inhibitory effect of JMB ethanol extract on tyrosinase activity and melanin contents in mouse melanoma cell line (B16F10 cell) was identified at 50, 100, 200 ㎍/㎖ levels by spectrometric assay. In each analysis, EGCG (epigallocatechin gallate) and Kojic acid were used as positive controls, respectively. Results : The elastase and collagenase inhibitory activity of JMB ethanol extract increased dose dependently. Also, The MTT assay showed that JMB, up to 400 ㎍/㎖ concentration, exhibited no toxic effect to the B16F10 cell. And following the JMB ethanol extract treat, cellular melanin contents and tyrosinase activity were dose-dependently decreased compared to those of control. Conclusion : These results suggest that JMB ethanol extract has effects to inhibitory activity on dermal wrinkle enzyme and melanogenesis. Therefore, JMB has applicable benefits for development of materials or products to have whitening and anti-aging functions on skin.
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참고문헌 (36)
참고문헌 신청
Royer / 2013 / Study of nutraceutical, nutricosmetics and cosmeceutical potentials of polyphenolic bark extracts from Canadian forest species / PharmaNutr 1:158~167
Fisher / 1999 / Molecular mechanisms of photoaging in human skin in vivo and their prevention by alltrans retinoic acid / Photochem. Photobiol 69(2):154~157
Shim / 2008 / The effects of panduratin A isolated from Kaempferia pandurata on the expression of matrix metalloproteinase-1 and type-1 procollagen in human skin fibroblasts / Planta medica 74(3):239~244
Kraunsoe / 1996 / Inhibition of human leukocyte and porcine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitor / Biochem 35:9090~9096
Shin / 2005 / H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo / J Invest. Dermatol 125(2):221
Fisher / 1999 / Molecular mechanisms of photoaging in human skin in vivo and their prevention by alltrans retinoic acid / Photochem. Photobiol 69(2):154~157
Shim / 2008 / The effects of panduratin A isolated from Kaempferia pandurata on the expression of matrix metalloproteinase-1 and type-1 procollagen in human skin fibroblasts / Planta medica 74(3):239~244
Kraunsoe / 1996 / Inhibition of human leukocyte and porcine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitor / Biochem 35:9090~9096
Shin / 2005 / H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo / J Invest. Dermatol 125(2):221
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