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Effects of Korean Red Ginseng on White Matter Microstructure and Cognitive Functions : A Focus on Intrusion Errors
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고려 홍삼이 대뇌 백질 미세구조 및 인지기능에 미치는 효과 : 침입 오류를 중심으로

논문 기본 정보

Type
Academic journal
Author
Jeong, Hyeonseok S. (가톨릭대학교 인천성모병원 영상의학과) Kim, Young Hoon (이화여자대학교 뇌융합과학연구원) Lee, Sunho (이화여자대학교 뇌융합과학연구원) Yeom, Arim (이화여자대학교 뇌융합과학연구원) Kang, Ilhyang (이화여자대학교 뇌융합과학연구원) Kim, Jieun E. (이화여자대학교 뇌융합과학연구원) Lee, Junghyun H. (이화여자대학교 뇌융합과학연구원) Ban, Soonhyun (이화여자대학교 뇌융합과학연구원) Lim, Soo Mee (이화여자대학교 뇌융합과학연구원)
Journal
Korean Society of Biological Psychiatry 생물정신의학 생물정신의학 제22권 제2호
Published
2015.1
Pages
78 - 86 (9page)

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Effects of Korean Red Ginseng on White Matter Microstructure and Cognitive Functions : A Focus on Intrusion Errors
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Objectives Although ginseng has been reported to protect neuronal cells and improve various cognitive functions, relationship between ginseng supplementation and response inhibition, one of the important cognitive domains has not been explored. In addition, effects of ginseng on in vivo human brain have not been investigated using the diffusion tensor imaging (DTI). The purpose of the current study is to investigate changes in intrusion errors and white matter microstructure after Korean Red Ginseng supplementation using standardized neuropsychological tests and DTI. Methods Fifty-one healthy participants were randomly allocated to the Korean Red Ginseng (n = 26) or placebo (n = 25) groups for 8 weeks. The California Verbal Learning Test was used to assess the number of intrusion errors. Intelligence quotient (IQ) was measured with the Korean Wechsler Adult Intelligence Scale. Depressive and anxiety symptoms were evaluated using Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and Hopkins Symptom Checklist-25. The fractional anisotropy (FA) was measured from the brain DTI data. Results After the 8-week intervention, Korean Red Ginseng supplementation significantly reduced intrusion errors after adjusting age, sex, IQ, and baseline score of the intrusion errors (p for interaction = 0.005). Change in FA values in the left anterior corona radiata was greater in the Korean Red Ginseng group compared to the placebo group (t = 4.29, p = 0.04). Conclusions Korean Red Ginseng supplementation may be efficacious for improving response inhibition and white matter microstructure integrity in the prefrontal cortex.

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