랫드의 기도로 투여된 투각섬석함유활석이 호흡기계에 미치는 영향 연구

정용현; 한정희; 강민구; 이성배; 김종규; 김현영; 양정선

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자료유형: 학술저널

저자정보: 정용현 (산업안전보건연구원 화학물질안전보건센터) 한정희 (산업안전보건연구원 화학물질안전보건센터) 강민구 (산업안전보건연구원 화학물질안전보건센터) 이성배 (산업안전보건연구원 화학물질안전보건센터) 김종규 (산업안전보건연구원 화학물질안전보건센터) 김현영 (산업안전보건연구원 화학물질안전보건센터) 양정선 (산업안전보건연구원 화학물질안전보건센터)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제20권 제2호

발행연도: 2010.1

수록면: 119 - 130 (12page)

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Pulmonary toxicity of talc containing tremolite asbestos (TCT) has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile(average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. TCT was analyzed for its physicochemical properties by transmission electron microscope equipped with energy dispersive X-ray spectrometer(TEM-EDS). The effects of 2mg TCT(talc average diameter 9.7${\pm}$8.4${\mu}m$; tremolite average diameter 1.6${\pm}$1.6${\mu}m$, average length 10.8${\pm}$7.0${\mu}m$) on pathological changes were evaluated after 1, 8 weeks instilled into rat lungs. 2mg Chrysotile continuously affected lung pathological changes. Inflammation and granuloma response broke out from 1 week after instilled with chrysotile and the pathological examination further showed increased legions of lung after 8 weeks. But TCT did not showed lung pathological changes. The biopersistence of TCT and chrysotile was evaluated by TEM- EDS. Whereas chrysotile continuously have retained to 8 weeks instilled into rat lungs, talc of TCT showed statistically significant decrease of diameter from 1 weeks and statistically significant change in Si atomic % compositions at 8 weeks instilled into rat lungs. Physicochemical properties of tremolite of TCT were not affected until 8 weeks instilled into rat lungs. This study showed that the durability of TCT in the lungs is much weaker than chrysotile.

#Talc containing tremolite #rat #biopersistence #intratracheal instillation #TEM-EDS

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