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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 20 - 26 (7page)
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Objectives: To evaluate the biodurability of Korean Chrysotile(KC), the changes in fibers numbers and changes in the element composition of fibers from the lung of Sprague-Dawley rats instilled KC(average size $4.74{\mu}m$, $59,043{\times}10^6$ fibers/mg) was estimated. Methods: Rats were administered 1 mg KC(low group) or 2 mg KC(high group) by a single intratracheal instillation. At each time point(5 days, 5 weeks, 10 weeks), the numbers of KC fibers and the changes of element composition(atomic %) of KC fibers from the lung of the rats were analyzed with transmission electron microscope equipped with energy dispersive X-ray spectrometer. Results: Over time, the number of fibers within the lungs of animals were reduced. The average length of the low and high group is significantly reduced from 5 days after administration. Over time, the fiber ratio of at least $5{\mu}m$ remaining in the lung tissue of the low concentration group was up but the high group was reduced. From day 5 after administration, the composition ratio(Mg) was significantly decreased in all groups. Conclusions: Size and composition of Korean Chrysotile in the lung tissue of rats was changed from 5 days.
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참고문헌 (11)
참고문헌 신청
Bernstein DM / 2003 / The biopersistence of Canadian chrysotile asbestos following inhalation / Inhal Toxicol 15(13):1247~1274
Bernstein DM / 2005 / Comparison of Calidria chrysotile asbestos to pure tremolite: final results of the inhalation biopersistence and histopathology following short term exposure / Inhal Toxicol 17:427~449
Bernstein DM / 2010 / The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure-interim results / Inhal Toxicol 22:937~962
Bernstein DM / 2011 / Quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite-asbestos following short-term inhalation exposure / Inhal Toxicol 23:372~391
정용현 / 2012 / 국내산 백석면과 안소필라이트의 물리화학적 특성과 호흡기계 내 변화 연구 / 한국산업보건학회지 22(3):224~234
Bernstein DM / 2005 / Comparison of Calidria chrysotile asbestos to pure tremolite: final results of the inhalation biopersistence and histopathology following short term exposure / Inhal Toxicol 17:427~449
Bernstein DM / 2010 / The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure-interim results / Inhal Toxicol 22:937~962
Bernstein DM / 2011 / Quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite-asbestos following short-term inhalation exposure / Inhal Toxicol 23:372~391
정용현 / 2012 / 국내산 백석면과 안소필라이트의 물리화학적 특성과 호흡기계 내 변화 연구 / 한국산업보건학회지 22(3):224~234
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