랫드에 투여된 규회석이 호흡기계에 미치는 영향 연구

정용현; 한정희; 강민구; 이성배; 김종규; 김현영; 양정선

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자료유형: 학술저널

저자정보: 정용현 (산업안전보건연구원 화학물질안전보건센터) 한정희 (산업안전보건연구원 화학물질안전보건센터) 강민구 (산업안전보건연구원 화학물질안전보건센터) 이성배 (산업안전보건연구원 화학물질안전보건센터) 김종규 (산업안전보건연구원 화학물질안전보건센터) 김현영 (산업안전보건연구원 화학물질안전보건센터) 양정선 (산업안전보건연구원 화학물질안전보건센터)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제20권 제4호

발행연도: 2010.1

수록면: 263 - 273 (11page)

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Occupational exposure to wollastonite can occur during its mining, processing and using. Wollastonite was analyzed for its physicochemical properties by transmission electron microscope and scanning electron microscope equipped with energy dispersive X-ray spectrometer. Wollastonite fibers were 3.3${\mu}m$ in diameter(av.) and were 30.5${\mu}m$ in length(av.). The atomic composition of wollastonite was Si 56.41% and Ca 43.59%. Respiratory toxicity of wollastonite has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile (average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. The effects of 2mg wollastonite on respiratory system and pathological changes were evaluated after 1, 4, 8, 12 weeks instilled into rat lungs. Inflammation response broke out from 1 week after instilled with wollastonite and the pathological examination further showed increased legions of granulomatous inflammation after 4 weeks, but decreased granulomatous inflammation after 8 weeks, whereas chrysotile induced progressive interstitial granulomatous inflammation and fibrosis as a function of time.

#Wollastonite #rat #intratracheal instillation

참고문헌 (48)

참고문헌 신청

Adachi S / 2001 / A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples / Ind. Health 39:168~174

Anonymous / 2002 / The trouble with tremolite-asbestiform mineral casts its shadow over wollastonite / Ind. Miner. 420:7

Anonymous / China makes paper with ore powder. People's Online Daily, June 13

Aslam M / 1995 / Red blood cell damage by wollastonite: In vitro study / J. Appl Toxicol. 15(1):27~31

Bank W / 1980 / Asbestiform and/or fibrous minerals in mines, mills, and quarries / USDepartment of Labor, Mine Safety and Health Administration

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