작업장에서 취급하는 CMR물질의 용량반응평가 방법 비교

이경화; 최한영; 김치년; 노영만; 최희진; 박채리

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자료유형: 학술저널

저자정보: 이경화 (을지대학교 보건환경안전과) 최한영 (연세대학교 의과대학 산업보건연구소) 김치년 (알켐송현[주]) 노영만 (알켐송현[주]) 최희진 (알켐송현[주]) 박채리 (Department of Health Environmental Safety, Eulji University)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제28권 제1호

발행연도: 2018.1

수록면: 51 - 60 (10page)

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Objectives: Currently, there is only limited knowledge regarding the hazard of low-level exposure to CMR materials in workplaces. To overcome this limitation, a reference concentration for workers($RfC_w$) from among the risk assessment tools proposed by the US EPA is widely used to set a provisional workplace exposure level(PWEL) for CMR materials for which there are no established Korea Occupational Exposure Limits(KOELs) or subjective chemicals for work environment measurements as regulated by Korea Ministry of Employment and Labor(KMOEL). A simple European calculator of derived no effect level(SECO-DNEL) as proposed by REACH can also be used in place of $RfC_w$ to set the PWEL for chemicals. This study was performed to test the acceptability of using SECO-DNEL as an alternative to $RfC_w$ when setting a PWEL for low-level exposures. Methods: The $RfC_w$ and DNEL for the five CMR materials of dinitrogen oxide, catechol, 2-phenoxy ethanol, carbitol, and carbon black were calculated using the dose-response assessments of the US EPA for $RfC_w$ and REACH guidance for SECO-DNEL, respectively. They were compared using paired t-tests to determine the statistical differences between them. Results: For the five chemicals, the $RfC_w$ were 2.53 ppm, 0.10 ppm, 1.73 ppm, 1.66 ppm, and $0.05mg/m^3$, respectively, while the SECO-DNEL were 2.01 ppm, 0.11 ppm, 1.83 ppm, 1.77 ppm, $0.14mg/m^3$, respectively. There was no statistically significant difference between $RfC_w$ and SECO-DNEL. Conclusions: This study suggests that the SECO-DNEL could be applied in place of $RfC_w$ to set a PWEL for low-level exposure to chemicals, especially CMR materials. To further ensure the reliability of SECO-DNEL as an alternative tool, more chemicals should be applied for calculation and comparison with $RfC_w$.

#CMR #dose-response #OEL #REACH #$RfC_w$ #SECO-DNEL

참고문헌 (26)

참고문헌 신청

Boojaard PJ / 2012 / A consistent and transparent approach for calculation of Derived No-Effect Levels (DNELs) for petroleum substances / Regulatory Toxicology and Pharmacology 62:85~98

European Commission (EC) / 2006 / Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Regulation (EC) No. 1907/2006 of the European Parliament and of the Council, L396/17:1.849 / Off. J. Eur. Commun

European Commission (EC) / 2006 / Regulation (EC) No. 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EC, 93/67/EEC, 93/105/ EC and 2001/21/EC. Vol. 1907/2006

European Chemicals Agency(ECHA) / 2008 / Guidance on Information Requirements and Chemical Safety Assessment, Part A: Introduction to the Guidance Document

European Chemicals Agency(ECHA) / 2008 / Guidance on Information Requirements and Chemical Safety Assessment Part B: Hazard Assessment

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