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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제5호
- 발행연도
- 2008.1
- 수록면
- 645 - 652 (8page)
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초록· 키워드
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Activated microglia produce diverse neurotoxic factors such as nitric oxide (NO) and prostaglandin $E_2\;(PGE_2)$ that may cause neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. From the EtOAc soluble fraction of Farfarae flos (Tussilago farfara), we purified tussilagone as a bioactive compound by monitoring the inhibitory potential of NO production in activated microglia through the purification procedures. Tussilagone showed dose-dependent inhibition of NO and $PGE_2$ production in LPS-activated microglia with $IC_{50}$ values of $8.67\;{\mu}M$ and $14.1\;{\mu}M$, respectively. It suppressed the expression of protein and mRNA of inducible nitric oxide synthase and cyclooxygenase-2 through the inhibition of I-${\kappa}B{\alpha}$ degradation and nuclear translocation of p65 subunit of NF-${\kappa}B$. Therefore tussilagone from Farfarae flos may have therapeutic potential in the treatment of neuro-inflammatory diseases through the inhibition of overproduction of NO and $PGE_2$.
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