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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 69 - 77 (9page)
이용수
초록· 키워드
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Objectives This study is to investigate whether oral administration of Farfarae flos, JCT (Jeong-cheon-tang), CPT (Cheong-pye-tang) and CPK (Cheong-pye-tang- ga-kwandonghwa) will affect both the levels of serum GOT, GPT, blood urea nitrogen (BUN) and creatinine in SD rats or not, and will change body weight of the rats.
Materials and Methods 18 SD rats were randomly divided into 6 groups . including a control group (vehicle 2 ml/rat), Farfarae flos water extract (extract 2 ml/rat), Farfarae flos fine powder (emulsion 2 ml/rat), JCT (extract 2 ml/rat), CPT (extract 2 ml/rat) and CPK (extract 2 ml/rat) group. The drugs were administered to rats for 2 weeks or 30 days (for control and Farfarae flos fine powder group only) and serum GOT/GPT activities and BUN/creatinine concentrations were measured. Also, the changes of body weights of each rat was measured.
Results (1) Farfarae flos water extract, Farfarae flos fine powder emulsion, JCT and CPT and CPK did not cause any changes in serum GOT/GPT activities and BUN/creatinine concentrations compared to the ones in control group.
(2) There are no significant changes in rats’ body weight among the experimental groups during the experimental period.
Conclusions Contrary to the reports on human data, 2 weeks or 30 days of oral administrations of Farfarae flos itself and decoctions containing Farfarae flos did not provoke hepatotoxicity and nephrotoxicity.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Oriental Herbalogy / 1999 / National Association of Oriental Herbalogy Professors / Younglimsa :482~483
Hwangbo C / 2009 / The anti-inflammatory effect of Tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages / Int Immunopharmacol 9(13-14):1578~1584
Sperl W / 1995 / Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea / Eur J Pediatr 154(2):112~116
Stegelmeier BL / 1999 / Pyrrolizidine alkaloid plants, metabolism and toxicity / J Nat Toxins 8(1):95~116
Roeder E / 2000 / Medicinal plants in China containing pyrrolizidine alkaloids / Pharmazie 55(10):711~726
Hwangbo C / 2009 / The anti-inflammatory effect of Tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages / Int Immunopharmacol 9(13-14):1578~1584
Sperl W / 1995 / Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea / Eur J Pediatr 154(2):112~116
Stegelmeier BL / 1999 / Pyrrolizidine alkaloid plants, metabolism and toxicity / J Nat Toxins 8(1):95~116
Roeder E / 2000 / Medicinal plants in China containing pyrrolizidine alkaloids / Pharmazie 55(10):711~726
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