Prolonged Antidiabetic Effect of Zinc-Crystallized Insulin Loaded Glycol Chitosan Nanoparticles in Type 1 Diabetic Rats

Jo, Hyung-Gon; Min, Kyung-Hyun; Nam, Tae-Hwan; Na, Seong-Ju; Park, Jae-Hyung; Jeong, Seo-Young

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자료유형: 학술저널

저자정보: Jo, Hyung-Gon (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) Min, Kyung-Hyun (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) Nam, Tae-Hwan (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) Na, Seong-Ju (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) Park, Jae-Hyung (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) Jeong, Seo-Young (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제7호

발행연도: 2008.1

수록면: 918 - 923 (6page)

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New basal insulin formulation was designed and their structural characteristics were investigated in vitro and biological activities in type 1 diabetic rats. Zinc-crystallized insulin was physically loaded into hydrophobically modified glycol chitosan (HGC) nanoparticles by a dialysis method. The series of insulin-HGC formulations were prepared with different feed weight ratio of insulin to HGC from 0.5:1 to 4:1. The loading contents of insulin and size distribution of insulin-HGCs were characterized, and blood glucose responses were investigated in streptozotocin-induced diabetic rats after single subcutaneous injection of regular insulin and insulin-HGCs. The highest loading efficiency and content were obtained in insulin-HGC when a 1:1 feed weight ratio of insulin to HGC was employed. The hydrodynamic diameter of insulin-HGC nanoparticles were in the range of 200 to 500 nm with narrow size distribution. Insulin-HGC effectively sustained insulin release up to 40% within 12 hours followed by a slower controlled release. Insulin-HGC showed an extended blood glucose lowering effect up to 24 h and provided normal blood glucose levels after oral glucose (1.5 g/kg) load at 24 hours post-injection while regular insulin showed severe hypoglycemia. The prolonged time action profiles and low variability of insulin-HGC formulation resulted in improved blood glucose control in diabetic rats and fulfilled a pattern desirable of a basal insulin.

#Basal insulin #Blood glucose control #Nanoparticles #Type 1 diabetes

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