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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제2호
- 발행연도
- 2008.1
- 수록면
- 160 - 166 (7page)
이용수
초록· 키워드
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FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb /scaria sinclarii, with agonistic effect for sphingosine-1-phosphate receptor. In this study, we examined the potential adverse effect of FTY720 in terms of cell cytotoxicity and the relevance to its pharmacological action, using cell proliferation assay and functional aspect of activated macrophages producing NO and $TNF-{\alpha}$. FTY720 potently blocked the proliferation of allogeneic T cells. However, this compound did not strongly suppress Con A-induced T cell blastogenesis and IL-2 induced CTLL-2 cell proliferation. Furthermore, FTY720 also non-specifically blocked the proliferation or viability of cancerous or primary cells tested, indicating its potential adverse effects. Interestingly, however, the non-specific inhibitory feature of FTY720 seems not to alter its pharmacological action, according to regulatory role of FTY720 on the production of $TNF-{\alpha}$ and NO from LPS-activated RAW264.7 cells, regardless of serum level. Therefore, our results suggest that FTY720 might have additional non-specific anti-proliferative activity, distinct from its pharmacological activity.
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